13 documents found, page 1 of 2
Medical cannabinoids for treatment of neuropsychiatric symptoms in dementia: a ...
Stella,Florindo; Valiengo,Leandro C. Lane; Paula,Vanessa J. R. de; Lima,Carlos Augusto de Mendonça; Forlenza,Orestes V.Abstract Introduction Neuropsychiatric symptoms are an integral component of the natural history of dementia, occurring from prodromal to advanced stages of the disease process and causing increased burden and morbidity. Clinical presentations are pleomorphic and clinical management often requires combinations of pharmacological and non-pharmacological interventions. However, limited efficacy and a non-negligib...
Mental health interventions following COVID-19 and other coronavirus infections...
Damiano,Rodolfo F.; Di Santi,Talita; Beach,Scott; Pan,Pedro M.; Lucchetti,Alessandra L.; Smith,Felicia A.; Forlenza,Orestes V.; Fricchione,Gregory L.Objective: To review the most common mental health strategies aimed at alleviating and/or preventing mental health problems in individuals during the coronavirus disease 2019 (COVID-19) and other coronavirus pandemics. Methods: We conducted a systematic review of the literature assessing three databases (PubMed, SCOPUS, and PsycINFO). A meta-analysis was performed with data from randomized controlled trials (RC...
Early diagnosis and treatment of Alzheimer’s disease: new definitions and chall...
Pais,Marcos; Martinez,Luana; Ribeiro,Octávio; Loureiro,Júlia; Fernandez,Romel; Valiengo,Leandro; Canineu,Paulo; Stella,Florindo; Talib,LedaThe prevalence of Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the “amyloid cascade” and the “continuum of AD,” discussed in this article, are now well established. From update...
Topography of 11C-Pittsburgh compound B uptake in Alzheimer’s disease: a voxel-...
Faria,Daniele de P.; Duran,Fabio L.; Squarzoni,Paula; Coutinho,Artur M.; Garcez,Alexandre T.; Santos,Pedro P.; Brucki,Sonia M.; de Oliveira,Maira O.Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer’s disease (AD), and explore possible group differences in 11C-PIB binding to white matter. Methods: 11C-PIB PET scans wer...
Correlation between CSF biomarkers of Alzheimer’s disease and global cognition ...
Radanovic,Márcia; Oshiro,Carlos A.; Freitas,Thiago Q.; Talib,Leda L.; Forlenza,Orestes V.Objective: The relationship between biomarkers of amyloid-beta aggregation (Aβ1-42) and/or neurodegeneration (Tau protein) in cerebrospinal fluid (CSF) and cognitive decline is still unclear. We aimed to ascertain whether CSF biomarkers correlate with cognitive performance in healthy and cognitively impaired subjects, starting from clinical diagnoses. Methods: We tested for correlation between CSF biomarkers an...
Art therapy as an adjuvant treatment for depression in elderly women: a randomi...
Ciasca,Eliana C.; Ferreira,Rita C.; Santana,Carmen L.A.; Forlenza,Orestes V.; dos Santos,Glenda D.; Brum,Paula S.; Nunes,Paula V.Objective: There are few quantitative studies on art therapy for the treatment of depression. The objective of this study was to evaluate if art therapy is beneficial as an adjuvant treatment for depression in the elderly. Methods: A randomized, controlled, single-blind study was carried out in a sample of elderly women with major depressive disorder (MDD) stable on pharmacotherapy. The experimental group (EG) ...
Increased CSF levels of total Tau in patients with subcortical cerebrovascular ...
Radanovic,Márcia; Stella,Florindo; Silva,Lis Gomes; Talib,Leda L.; Forlenza,Orestes V.ABSTRACT. Cognitive impairment includes mild cognitive decline and dementia, such as Alzheimer's disease (AD) and cerebrovascular-related pathologies. Objective: To investigate the profile of AD-related CSF biomarkers in a sample of cognitively impaired and unimpaired older adults with concomitant subcortical cerebrovascular burden. Methods: Seventy-eight older adults attending an outpatient psychogeriatric cli...
Mild cognitive impairment (part 1): clinical characteristics and predictors of ...
Forlenza,Orestes V.; Diniz,Breno S.; Stella,Florindo; Teixeira,Antonio L.; Gattaz,Wagner F.Objective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based ...
Mild cognitive impairment (part 2): biological markers for diagnosis and predic...
Forlenza,Orestes V.; Diniz,Breno S.; Teixeira,Antonio L.; Stella,Florindo; Gattaz,WagnerObjective: To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD). Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012, and based on the following terms: mild cognitive impairment, Alzhe...
Criteria for the diagnosis of Alzheimer's disease: Recommendations of the Scien...
Frota,Norberto Anízio Ferreira; Nitrini,Ricardo; Damasceno,Benito Pereira; Forlenza,Orestes V.; Dias-Tosta,Elza; Silva,Amauri B. daAbstract This consensus prepared by the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology is aimed at recommending new criteria for the diagnosis of dementia and Alzheimer's disease (AD) in Brazil. A revision was performed of the proposals of clinical and of research criteria suggested by other institutions and international consensuses. The new proposal for the diagno...