4 documents found, page 1 of 1
Lanthanide-Based Organic Salts
Forte, Andreia; Gago, Sandra; Alves, Celso; Silva, Joana; Alves, Joana; Pedrosa, Rui; Laia, César A. T.; Marrucho, Isabel M.; Branco, Luís C.The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. Th...
A solvent‐free strategy to prepare amorphous salts of folic acid with enhanced ...
Martins, Inês C. B.; Forte, Andreia; Diogo, Hermínio P.; Raposo, Luís R.; Baptista, Pedro V.; Fernandes, Alexandra R.; Branco, Luís C.Eight new amorphous organic salts of folic acid (FA) were prepared by mechanochemistry. FA can prevent cardiovascular and neurological diseases. Mechanochemistry overcomes serious FA solubility issues avoiding the use of toxic solvents. Due to low FA solubility, therapeutic effects in supplements and drugs are not achieved. Current strategies to improve FA solubility include its derivatization by using complex ...
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesopo...
Mora, Blanca de Juan; Filipe, Luís; Forte, Andreia; Santos, Miguel M.; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Carrott, Manuela RibeiroUID/MAR/04292/2020 PEst-C/LA0006/2013 RECI/BBBBQB/0230/2012 MAR-02.01.01-FEAMP-0042–INOVA4AQUA 022161; Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of...
Novel biocompatible ionic liquids based on gluconate anion
Costa, Alexandra; Forte, Andreia; Zalewska, Karolina; Tiago, Gonçalo; Petrovski, Zeljko; Branco, Luís C.A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studi...