52 documents found, page 1 of 6
Liposomal formulations loaded with a eugenol derivative for application as inse...
Fernandes, Maria José Gomes; Pereira, Renato B.; Rodrigues, Ana Rita Oliveira; Vieira, Tatiana F.; Fortes, A. Gil; Pereira, David M.; Sousa, Sérgio F.A recently synthesized new eugenol derivative, ethyl 4-(2-methoxy-4-(oxiran-2-ylmethyl)phenoxy)butanoate, with a high insecticidal activity against Sf9 (Spodoptera frugiperda) insect cells, was encapsulated in the liposomal formulations of egg-phosphatidylcholine/cholesterol (Egg-PC:Ch) 70:30 and 100% dioleoylphosphatidylglycerol (DOPG), aiming at the future application as insecticides. Compound-loaded DOPG lip...
Eugenol β-amino/β-alkoxy alcohols with selective anticancer activity
Teixeira, Cláudia; Pereira, Renato B.; Pinto, Nuno F. S.; Coelho, Catarina M. M.; Fernandes, Maria José G.; Fortes, A. Gil; Gonçalves, M. Sameiro T.Eugenol, 4-allyl-2-methoxyphenol, is the main constituent of clove essential oil and has demonstrated relevant biological activity, namely anticancer activity. Aiming to increase this activity, we synthesized a series of eugenol β-amino alcohol and β-alkoxy alcohol derivatives, which were then tested against two human cancer cell lines, namely gastric adenocarcinoma cells (AGS) and lung adenocarcinoma cells (A5...
Synthesis, computational and nanoencapsulation studies on eugenol-derived insec...
Coelho, Catarina M. M.; Pereira, Renato B.; Vieira, Tatiana F.; Teixeira, Cláudia M.; Fernandes, Maria José Gomes; Rodrigues, Ana Rita O.A new set of alkoxy alcohols were synthesised by reaction of eugenol oxirane with aliphatic and aromatic alcohols. These eugenol derivatives were evaluated against their effect upon the viability of the insect cell line Sf9 (Spodoptera frugiperda). The most promising compounds, 4-(3-(tert-butoxy)-2-hydroxypropyl)-2-methoxyphenol and 4-(2-((4-fluorobenzyl)oxy)-3-hydroxypropyl)-2-methoxyphenol were submitted to i...
New carvacrol and thymol derivatives as potential insecticides: synthesis, biol...
Natal, Carolina M.; Fernandes, Maria José Gomes; Pinto, Nuno F. S.; Pereira, Renato B.; Vieira, Tatiana F.; Rodrigues, Ana Rita OliveiraNew compounds with potential insecticide activity were synthesized by structural modifications performed in the monoterpenoids phenolic moieties of carvacrol and thymol, resulting in a set of derivatives with the ether function containing the propyl, chloropropyl or hydroxypropyl chains, as well as a bicyclic ether with an unsaturated chain containing a carboxylic acid terminal. In addition, an analogue of carv...
Eugenol derivatives with potential insecticide activity
Coelho, José Ricardo Alves; Fernandes, Maria José Gomes; Pereira, David M.; Castanheira, Elisabete M. S.; Fortes, A. Gil; Gonçalves, M. Sameiro T.In the present work, semisynthetic eugenol derivatives were obtained through epoxidation reaction followed by epoxide opening with nucleophiles, such as sodium azide and sodium cyanide. The optimization of the various reactions was performed using different experimental conditions. The main objective behind obtaining these eugenol derivatives was their evaluation as alternative insecticides, thus the biological...
Amino alcohols from eugenol as potential semisynthetic insecticides: chemical, ...
Pereira, Renato B.; Pinto, Nuno F. S.; Fernandes, Maria José Gomes; Vieira, Tatiana F.; Rodrigues, Ana Rita Oliveira; Pereira, David M.A series of β-amino alcohols were prepared by the reaction of eugenol epoxide with aliphatic and aromatic amine nucleophiles. The synthesized compounds were fully characterized and evaluated as potential insecticides through the assessment of their biological activity against Sf9 insect cells, compared with a commercial synthetic pesticide (chlorpyrifos, CHPY). Three derivatives bearing a terminal benzene ring,...
Natural pigments of anthocyanin and betalain for coloring soy-based yogurt alte...
Dias, Sandra; Castanheira, Elisabete M. S.; Fortes, A. Gil; Pereira, David M.; Gonçalves, M. Sameiro T.The aim of this work was to evaluate the color stability of betalain- and anthocyanin-rich extracts in yogurt-like fermented soy, in order to develop a preliminary understanding of how these pigments behave in this type of food system during storage for 21 days at 4 °C. Thus, the extracts of red beetroot, opuntia, hibiscus and red radish were integrated into the yogurt-like fermented soy in two different ways—d...
New eugenol derivatives with enhanced insecticidal activity
Fernandes, Maria José Gomes; Pereira, Renato B.; Pereira, David M.; Fortes, A. Gil; Castanheira, Elisabete M. S.; Gonçalves, M. Sameiro T.Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New <i>O</i>-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were lat...
Application of natural pigments in ordinary cooked ham
Dias, Sandra; Castanheira, Elisabete M. S.; Fortes, A. Gil; Pereira, David M.; Rodrigues, Ana Rita Oliveira; Pereira, Regina; Gonçalves, M. Sameiro T.The possibility of obtaining a carmine or pink color on ordinary cooked ham by applying natural dyes from three plant species, namely red radish (<i>Raphanus sativus</i> L.), hibiscus (<i>Roselle sabdariffa</i> L.) and red beetroot (<i>Beta vulgaris</i> L.), was investigated. The extracts were evaluated for the stability at physical-chemical parameters and subjected to cytotoxicity assays in the gastric cell li...
Cytotoxic plant extracts towards insect cells: bioactivity and nanoencapsulatio...
Lopes, Ana I. F.; Monteiro, Mariana; Araújo, Ana Rita L.; Rodrigues, Ana Rita Oliveira; Castanheira, Elisabete M. S.; Pereira, David M.; Olim, PedroThe potential of plant extracts as bioinsecticides has been described as a promising field of agricultural development. In this work, the extracts of Punica granatum (pomegranate), Phytolacca americana (American pokeweed), Glandora prostrata (shrubby gromwell), Ulex europaeus (gorce), Tagetes patula (French marigold), Camellia japonica red (camellia), Ruta graveolens (rue or herb-of-grace) were obtained, purifi...