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Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed proma...
Mayrink,Wilson; Santos,Gilmara Cristina dos; Toledo,Vicente de Paulo Coelho Peixoto de; Guimarães,Tânia Mara Pinto DabésAntigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences we...
Date: 2002
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Origin: Oasisbr