25 documents found, page 1 of 3
Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, A.; Bicker, Joana; Sánchez-López, Elena; Paz, Cristian; Ureña, Jesús; Verdaguer, EsterLicochalcone A (Lico-A) is a flavonoid compound derived from the root of the Glycyrrhiza species, a plant commonly used in traditional Chinese medicine. While the Glycyrrhiza species has shown promise in treating various diseases such as cancer, obesity, and skin diseases due to its active compounds, the investigation of Licochalcone A's effects on the central nervous system and its potential application in Alz...
Is preoperative chemosensitivity associated with improved outcomes in locally a...
Caleça, T.; Honório, M.; Sousa, M.; Ribeiro, J.; Fortuna, A.; Silva, D. Neto da; Albuquerque, J.; Menezes, M.; Trabulo, C.; Costa, D.Perioperative chemotherapy (PCT) is the standard of care for locally advanced gastric cancer (LAGC) in western countries. However, less than 60% of patients complete the adjuvant part of treatment due to postoperative complications, toxicity and disease progression (DP). This study aim is to evaluate if preoperative chemosensitivity (POCS) is associated with improved overall survival (OS) and disease free survi...
A long-term survivors of glioblastoma: a single-centre retrospective study
Fortuna, A.; Luz, P.; Cordeiro, M.Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet, despite advancements in understanding its biology, it remains an incurable disease with a high mortality rate. Less than 5% of patients survive beyond 5 years, making identification of factors associated with long-term survival critical in improving outcomes for patients with glioblastoma.
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in b...
Pinho, A. R.; Fortuna, A.; Falcão, A. N.; Santos, A. C.; Seiça, R.; Estevens, C.; Veiga, F.; Ribeiro, A. J.The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required to develop several quantification methods for GLP-1 analogs products, ...
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review...
Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; Machado, Ana López; Severino, Patrícia; Jose, Sajan; Santini, Antonello; Fortuna, A.Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adv...
Subtelomeric Rearrangements: Presentation of 21 Probands with Emphasis on Famil...
Soares, A.; Soares, G.; Mota-Freitas, M.; Oliva-Teles, N.; Fortuna, A.Intellectual disability affects 2% - 3% of the general population, with a chromosomal abnormality being found in 4% - 28% of these patients and a cryptic subtelomeric abnormality in 3% - 16%. In most cases, these subtelomeric rearrangements are submicroscopic, requiring techniques other than conventional karyotype for detection. They may be de novo or inherited from an affected parent or from a healthy carrier ...
Infantile Refsum Disease: Influence of Dietary Treatment on Plasma Phytanic Aci...
Sá, M.; Rocha, J.; Almeida, M.; Carmona, C.; Martins, E.; Miranda, V.; Coutinho, M.; Ferreira, R.; Pacheco, S.; Laranjeira, F.; Ribeiro, I.; Fortuna, A.Infantile Refsum disease (IRD) is one of the less severe of Zellweger spectrum disorders (ZSDs), a group of peroxisomal biogenesis disorders resulting from a generalized peroxisomal function impairment. Increased plasma levels of very long chain fatty acids (VLCFA) and phytanic acid are biomarkers used in IRD diagnosis. Furthermore, an increased plasma level of phytanic acid is known to be associated with neuro...
Unraveling the pathogenesis of ARX polyalanine tract variants using a clinical ...
Marques, I.; Sá, J.; Soares, G.; Mota, M.; Pinheiro, C.; Aguiar, L.; Amado, M.; Soares, C.; Calado, A.; Dias, P.; Sousa, A.; Fortuna, A.; Santos, R.The Aristaless-related homeobox (ARX) gene is implicated in intellectual disability with the most frequent pathogenic mutations leading to expansions of the first two polyalanine tracts. Here, we describe analysis of the ARX gene outlining the approaches in the Australian and Portuguese setting, using an integrated clinical and molecular strategy. We report variants in the ARX gene detected in 19 patients belon...
Síndroma Smith-Lemli-Opitz. Defeito Metabólico na Biossíntese do Colesterol. A ...
R. Mota, Céu; Martins, E.; Fortuna, A.; Carvalho, C.; Proneça, E.; Matos, A.; Pinho, O.; Barbot, C.; Lima, M. R.O síndroma de Smith-Lemli-Opitz (SLO) é uma doença genética autossómica recessiva caracterizada por múltiplas anomalias congénitas sendo as mais frequentes o atraso de crescimento e desenvolvimento, microcefalia, anomalias faciais, anomalias genitais e sindactilia e ou polidactilia associadas a outras anomalias menos frequentes. Não há nenhuma anomalia congénita patognomónica nem obrigatória para o diagnóstico ...
A 26-Year Experience in Chorionic Villus Sampling Prenatal Genetic Diagnosis
Jorge, P.; Mota-Freitas, M.; Santos, R.; Silva, M.; Soares, G.; Fortuna, A.Abstract: This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study relate to the following: sampling method, referral reason versus abnormality and incid...