14 documents found, page 1 of 2
Unlocking the role of metabolic pathways in brain metastatic disease
Pinto, Madalena; Violante, Sara; Cascao, Rita; Faria, ClaudiaThe dissemination of malignant cells to the brain is a late-stage complication of cancer, leading to significant morbidity and mortality. Brain metastases (BM) affect 20-30% of cancer patients, primarily originating from lung cancer, breast cancer, and melanoma. Despite advances in molecular-targeted therapies, brain metastatic disease remains incurable, with a poor median survival of ≤12 months if left untreat...
Immunotherapy in lung cancer brain metastases
Paisana, Eunice; Cascao, Rita; Alvoeiro, Magda; Félix, Francisco; Martins, Guilherme; Guerreiro, Carla; Roque, Rafael; Cruz, Rafael Moiteiro DaBrain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunothera...
Role of UBE2C in brain cancer invasion and dissemination
Domentean, Stefani; Paisana, Eunice; Cascao, Rita; Faria, ClaudiaGlioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary or metastatic brain cancer cells, whose triggering mechanisms are largely unknown. Emerging evidence has suggested that the ubiquitin-conjugating enzyme E2C (UBE2C)...
Integrative multi-omics reveals two biologically distinct groups of pilocytic a...
Picard, Daniel; Felsberg, Jörg; Langini, Maike; Stachura, Paweł; Qin, Nan; Macas, Jadranka; Reiss, Yvonne; Bartl, Jasmin; Selt, Florian; Sigaud, RomainPilocytic astrocytoma (PA), the most common pediatric brain tumor, is driven by aberrant mitogen-activated protein kinase signaling most commonly caused by BRAF gene fusions or activating mutations. While 5-year overall survival rates exceed 95%, tumor recurrence or progression constitutes a major clinical challenge in incompletely resected tumors. Here, we used similarity network fusion (SNF) analysis in an in...
Usefulness of a clinicopathological classification in predicting treatment-rela...
Peixe, Carolina; Alexandre, Maria Inês; Gomes, Ana Raquel; Nobre, Ema; Silva, Ana Luísa; Oliveira, Tiago; Lopez-Presa, Dolores; Faria, ClaudiaPurpose: A clinicopathological classification has been designed to predict recurrence/progression in patients with pituitary adenomas (PAs). We aimed to study its usefulness in predicting PAs that will have a challenging disease course and may require more often complex multimodal and multiple therapeutic approaches. Methods: Retrospective analysis of 129 patients with PAs operated in our institution between 20...
Stratification of radiosensitive brain metastases based on an actionable S100A9...
Monteiro, Cátia; Miarka, Lauritz; Perea-García, María; Priego, Neibla; García-Gómez, Pedro; Álvaro-Espinosa, Laura; de Pablos-Aragoneses, AnaWhole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have questioned the clinical impact of this approach and emphasized the need for alternative treatments. Given the limited therapeutic options available for these patients and the poor understanding of the molecular mechanisms unde...
The microenvironment of pituitary adenomas: biological, clinical and therapeuti...
Marques, Pedro; Silva, Ana Luísa; López Presa, Dolores; Faria, Claudia; Bugalho, Maria JoãoThe microenvironment of pituitary adenomas (PAs) includes a range of non-tumoral cells, such as immune and stromal cells, as well as cell signaling molecules such as cytokines, chemokines and growth factors, which surround pituitary tumor cells and may modulate tumor initiation, progression, invasion, angiogenesis and other tumorigenic processes. The microenvironment of PAs has been actively investigated over t...
The transcriptional landscape of Shh medulloblastoma
Skowron, Patryk; Farooq, Hamza; Cavalli, Florence M. G.; Morrissy, A. Sorana; Ly, Michelle; Hendrikse, Liam D.; Wang, Evan Y.; Djambazian, HaigSonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the ...
Clinical outcomes and patient-matched molecular composition of relapsed medullo...
Kumar, Rahul; Smith, Kyle S.; Deng, Maximilian; Terhune, Colt; Robinson, Giles W; Orr, Brent A.; Liu, Anthony P. Y.; Lin, Tong; Billups, Catherine A.Purpose: We sought to investigate clinical outcomes of relapsed medulloblastoma and to compare molecular features between patient-matched diagnostic and relapsed tumors. Methods: Children and infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced medulloblastoma relapse were analyzed for clinical outcomes, including anatomic and temporal patterns of relapse and postrelaps...
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
Guerreiro Stucklin, Ana S.; Ryall, Scott; Fukuoka, Kohei; Zapotocky, Michal; Lassaletta, Alvaro; Li, Christopher; Bridge, Taylor; Kim, ByungjinInfant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of cl...