2 documents found, page 1 of 1
Streptococcus canis are a single population infecting multiple animal hosts des...
Pinho, MD; Foster, G; Pomba, C.; Machado, MP; Baily, JL; Kuiken, T; Melo-Cristino, J; Ramirez, M; Vaz, T; Giao, MABSTRACT - Streptococcus canis is an animal pathogen which occasionally causes infections in humans. The S. canis M-like protein (SCM) encoded by the scm gene, is its best characterized virulence factor but previous studies suggested it could be absent in a substantial fraction of isolates. We studied the distribution and variability of the scm gene in 188 S. canis isolates recovered from companion animals (n =...
STARTVerso1: A Randomized Trial of Faldaprevir Plus Pegylated Interferon/Ribavi...
Ferenci, P; Asselah, T; Foster, G; Zeuzem, S; Sarrazin, C; Moreno, C; Ouzan, D; Maevskaya, M; Calinas, F; Morano, L; Crespo, J; Dufour, JF; Bourlière, MBACKGROUND & AIMS: The efficacy and tolerability of faldaprevir, a potent hepatitis C virus (HCV) NS3/4A protease inhibitor, plus peginterferon (PegIFN) and ribavirin (RBV) was assessed in a double-blind, placebo-controlled phase 3 study of treatment-naïve patients with HCV genotype-1 infection. METHODS: Patients were randomly assigned (1:2:2) to PegIFN/RBV plus: placebo (arm 1, n = 132) for 24 weeks; faldaprev...