Made available in DSpace on 2015-05-15T13:30:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2014; Calcific aortic valve disease (CAVD) is a chronic disorder characterized by an abnormal mineralization of the leaflets, which is accelerated in bicuspid aortic valve (BAV). It is suspected that mechanical strain may promote/enhance mineralization of the aortic valve. However, the effect of mechanical strain a...