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A novel approach to assess balneotherapy effects on musculoskeletal diseases - ...

Silva, Jani; Martins, José; Nicomédio, Cristina; Gonçalves, Catarina; Palito, Cátia; Gonçalves, Ramiro Manuel; Fernandes, Paula Odete; Nunes, Alcina

The present study aimed to evaluate whether a 14-day period of balneotherapy influences the inflammatory status, health-related quality of life (QoL) and quality of sleep, underlying overall health state, and clinically relevant benefits of patients with musculoskeletal diseases (MD). The health-related QoL was evaluated using the following instruments: 5Q-5D-5L, EQ-VAS, EUROHIS-QOL, B-IPQ, and HAQ-DI. The qual...

Date: 2023   |   Origin: Biblioteca Digital do IPB

Alkaloids from fungi

Silva, Jani; Garcia, Juliana; Guimarães, Rafaela; Palito, Cátia; Lemos, André; Barros, Lillian; Alves, Maria José

The prospection of unusual sources and undiscovered habitats is valuable in natural product research. Indeed, the fungi kingdom has received special attention since its ability to produce novel and intriguing secondary metabolites with various biological uses. Among secondary metabolites, alkaloid-derived structures present a wide range of bioactivities, including antineurodegenerative, antidepressive, anxiolyt...

Date: 2023   |   Origin: Biblioteca Digital do IPB

Development and validation of a RP-HPLC method for the simultaneous analysis of...

Encarnação, Telma; Aguiar, António; Palito, Cátia; Pais, Alberto A. C. C.; Campos, Maria G.; Sobral, Abílio J. F. N.; Burrows, Hugh D.

A rapid reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous quantification of paracetamol, ibuprofen, olanzapine, simvastatin and simvastatin acid in the context of microalgae bioremediation. The method was validated according to the guidelines of the US Food and Drug Administration (FDA), the International Conference on Harmonization (ICH), and...


Removal of Pharmaceuticals from Water by Free and Imobilised Microalgae

Encarnação, Telma; Palito, Cátia; Pais, Alberto A. C. C.; Valente, Artur J. M.; Burrows, Hugh D.

Pharmaceuticals and their metabolites are released into the environment by domestic, hospital, and pharmaceutical industry wastewaters. Conventional wastewater treatment technology does not guarantee effluents of high quality, and apparently clean water may be loaded with pollutants. In this study, we assess the performance and efficiency of free and immobilised cells of microalgae Nannochloropsis sp. in removi...


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