15 documents found, page 1 of 2
Leprosy case series in the emergency room: A warning sign for a challenging dia...
Bernardes-Filho,Fred; Lima,Filipe Rocha; Voltan,Glauber; Paula,Natália Aparecida de; Frade,Marco Andrey CiprianiABSTRACT Leprosy can be considered a dissimulated disease, mainly when presented as atypical cases leading to mistaken diagnosis at the emergency setting. Herein we report six patients referred to the emergence room with hypotheses of acute myocardial infarction and arterial and venous thrombosis, although with chronic neurological symptoms; the seventh patient was referred with a wrong suspicion of infected sk...
Healing effects of natural latex serum 1% from Hevea brasiliensis in an experim...
Leite,Marcel Nani; Leite,Saulo Nani; Caetano,Guilherme Ferreira; Andrade,Thiago Antônio Moretti de; Fronza,Márcio; Frade,Marco Andrey CiprianiAbstract Background Dermabrasion is related with mechanical and surgical traumas on the skin; usually topical antiseptics and/or saline have been used for healing. Natural products for wound healing can also be used for abrasions, such as latex from Hevea brasiliensis. Objective This study aimed to evaluate the in vitro viability and migratory/proliferative effects of latex serum from H. brasiliensis and to com...
Consensus on the diagnosis and management of chronic leg ulcers - Brazilian Soc...
Abbade,Luciana Patricia Fernandes; Frade,Marco Andrey Cipriani; Pegas,José Roberto Pereira; Dadalti-Granja,Paula; Garcia,Lucas CamposAbstract Background: Chronic leg ulcers affect a large portion of the adult population and cause a significant social and economic impact, related to outpatient and hospital care, absence from work, social security expenses, and reduced quality of life. The correct diagnosis and therapeutic approach are essential for a favorable evolution. Objective: To gather the experience of Brazilian dermatologists, reviewi...
Anti-fibrotic effects of rosmarinic acid on Tenon’s capsule fibroblasts stimula...
Módulo,Carolina Maria; Ferreira,Larissa Domenegueti; Silva,Lilian Eslaine Costa Mendes da; Frade,Marco Andrey Cipriani; Reinach,Peter SolABSTRACT Purpose: Collagen deposition and myofibroblast differentiation are critical factors related to excessive scarring in ocular surgeries. This study evaluated the anti-fibrotic activity of rosmarinic acid on rabbit Tenon’s capsule fibroblasts stimulated with transforming growth factor- β2. Methods: Primary cultures of rabbit Tenon’s capsule fibroblasts were treated with various concentrations of rosmarini...
Epidermal necrolysis: SCORTEN performance in AIDS and non-AIDS patients
Wambier,Carlos Gustavo; Hoekstra,Thaís Angélica; Wambier,Sarah Perillo de Farias; Bueno Filho,Roberto; Vilar,Fernando CrivelentiAbstract: Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening blistering drug reactions with high incidence of ocular sequela. The term ‘Epidermal Necrolysis’ has been recently used to better describe the full spectrum of the disease that includes Stevens-Johnson syndrome and toxic epidermal necrolysis at opposite ends, which differ by the extent of body surface area with ep...
Factors associated with seropositivity for APGL-Iamong household contacts of le...
Wambier,Carlos Gustavo; Wambier,Sarah Perillo de Farias; Furini,Renata Bazan; Simão,João Carlos Lopes; Frade,Marco Andrey CiprianiAbstract: INTRODUCTION: Leprosy is mainly transmitted among family members who share genetic and ambient factors. The clinical form of leprosy in the index case and kinship could be risk factors for leprosy transmission. High antibody levels in household contacts (HC) in the absence of neural or skin lesions may characterize latent infection. This study aimed to evaluate the association between seropositivity f...
Prolonged viability of human organotypic skin explant in culture method (hOSEC)
Frade,Marco Andrey Cipriani; Andrade,Thiago Antônio Moretti de; Aguiar,Andréia Fernanda Carvalho Leone; Guedes,Flávia Araújo; Leite,Marcel NaniAbstract BACKGROUND: Currently, the cosmetic industry is overwhelmed in keeping up with the safety assessment of the increasing number of new products entering the market. To meet such demand, research centers have explored alternative methods to animal testing and also the large number of volunteers necessary for preclinical and clinical tests. OBJECTIVES: This work describes the human skin ex-vivo model (hOSE...
Phototherapy promotes healing of cutaneous wounds in undernourished rats
Leite,Saulo Nani; Andrade,Thiago Antônio Moretti de; Masson-Meyers,Daniela dos Santos; Leite,Marcel Nani; Enwemeka,Chukuka S.BACKGROUND: Various studies have shown that phototherapy promotes the healing of cutaneous wounds. OBJECTIVE: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats. METHODS: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernouris...
The vegetal biomembrane in the healing of chronic venous ulcers
Frade,Marco Andrey Cipriani; Assis,Raimunda Violante Campos de; Coutinho Netto,Joaquim; Andrade,Thiago Antônio Moretti de; Foss,Norma TiraboschiBACKGROUND: The vegetal biomembrane has been used to treat cutaneous ulcers. OBJECTIVES: To assess the role of the vegetal biomembrane on the chronic venous ulcers treatment compared to treatment with collagenase cream. METHODS: Fourteen patients were selected to be treated with vegetal biomembrane and 7 with Fibrase®(CONTROL), followed clinically and photographically by the Wound Healing Index by ImageJ during...
Modelos experimentais de desnutrição e sua influência no trofismo cutâneo
Leite,Saulo Nani; Jordão Júnior,Alceu Afonso; Andrade,Thiago Antônio Moretti de; Masson,Daniela dos Santos; Frade,Marco Andrey CiprianiFUNDAMENTOS: A pele, para exercer suas funções, necessita de níveis adequados de nutrientes. OBJETIVO: Analisar o trofismo cutâneo de ratos nutridos e desnutridos por meio de dois modelos de desnutrição. MÉTODOS: No Modelo Marasmo, utilizaram-se 60 ratos Wistar em controle dietético, dos quais 30 foram selecionados aleatoriamente para receber metade da dieta diária durante 60 dias. No Modelo Gelatina, empregara...