16 documents found, page 1 of 2
Viability assay and DNA double strand break induction in nervous system cells e...
Fernandez-Bertolez, N.; Touzani, A.; Martinez, L.; Méndez, J.; Ramos-Paz, L.; Reis, A.T.; Fraga, S.; Costa, C.; Teixeira, J.P.; Pásaro, E.Cerium dioxide nanoparticles (CeO2 NP) show antioxidant enzyme mimetic properties and free radical scavenging activity. These properties make them a promising material for biomedical applications, but their potential adverse effects are not totally understood yet. Our objective was to assess the biological behaviour of CeO2 NP in human neuronal and glial cells. After carrying out the physical-chemical character...
Comparative analysis of the toxicity profile of eleven consumer-relevant nanoma...
Pires, J.; Moreira, L.; Teixeira, J. P.; Fraga, S.Background: The growing number of items incorporating nanomaterials (NM) has prompted considerable concerns about human health and safety [1]. Metal nanoparticles, inorganic non-metallic, and carbon-based NM are among the types with the highest market volume [2]. Objective: The purpose of this study was to determine the effect of chemical composition [Ag, Au, TiO2, SiO2, and graphene oxide (nano_GO)], primary s...
Utility of salivary leucocytes for biomonitoring of human exposure to nanomater...
Valdiglesias, Vanessa; Fernández-Bertólez, Natália; Touzani, A.; Mendéz, J.; Martinez, L.; Pásaro, E.; Reis, A.T.; Fraga, S.; Teixeira, J.P.; Costa, C.Metal-based nanoparticles (NP) are being increasingly used in a wide variety of applications in consumer products and biomedical practices. As a result, human exposure to these nanomaterials is frequent, becoming a concern to public health. Human salivary leucocytes have been proposed as a proper biological sample for the comet assay, becoming an adequate non-invasive alternative model to evaluate DNA damage. I...
In vitro toxicity of metal nanoparticles in two human barrier models: role of t...
Pires, J; Moreira, L; Teixeira, J.P.; Fraga, S.Metal nanoparticles (M-NP) are among the most widely used nanomaterials in consumer products available in the market. Thus, human exposure to these nanosized materials is increasing, which raises serious concerns regarding their environmental and human safety. Biological barriers are important lines of defence to xenobiotics, thus expected targets for M-NP. The present study aimed at evaluating the in vitro tox...
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applicat...
Neves, C. S.; Sousa, L.; Freitas, M. A.; Costa, C.; Teixeira, J. P.; Fraga, S.; Pinto, Edgar; Almeida, A.; Scharnagl, N.; Zheludkevich, M. L.MgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectros...
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applicat...
Neves, C.S.; Sousa, I.; Freitas, M.A.; Moreira, L.; Costa, C.; Teixeira, J.P.; Fraga, S.; Pinto, E.; Almeida, A.; Scharnagl, N.; Zheludkevich, M.L.MgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectros...
In vitro acute toxicity of metal-based nanoparticles in human trophoblast BeWo ...
Pires, J.; Moreira, L.; Teixeira, J.P.; Fraga, S.Metal nanoparticles (M-NP) are among the most widely used nanomaterials in consumer products available in the market. Thus, human exposure to these nanosized materials is increasing, which raises serious concerns regarding their environmental and human safety. Biological barriers are important lines of defence to xenobiotics, thus expected targets for M-NP. In this regard, special consideration must be given to...
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applicat...
Neves, C. S.; Sousa, Isabel; Freitas, Maria Adriana; Moreira, L.; Costa, C.; Teixeira, J. P.; Fraga, S.; Pinto, E.; Almeida, A.; Scharnagl, N.MgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectros...
Involvement in maternal care by migrants and ethnic minorities: a narrative review
Freitas, C.; Massag, J.; Amorim, M.; Fraga, S.Background Guidelines for improving the quality of maternal health services emphasise women's involvement in care. However, evidence about migrant and ethnic minorities' preferences for participation in maternal care remains unsystematised. Understanding these populations' experiences with and preferred forms of involvement in care provision is crucial for imbuing policies and guidelines with sensitivity to div...
Insights into the role of the physicochemical properties in the toxicity of SiO...
Brandão, M.F.P.; Bessa, M.J.; Costa, C.; Fraga, S.; Haase, A.; Teixeira, J.P.Silica nanoparticles (SiO2 NPs) are easily produced in different sizes and surface modifications enabling their use in several industrial and biomedical applications, which increases the risk of human exposure to these nanoparticles. Because the toxicological profile of nanoparticles is dependent upon their physicochemical properties, the aim of this study was to investigate the influence of the physicochemical...