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Design, synthesis and antiparasitic evaluation of click phospholipids

Magoulas, GE; Afroudakis, P; Georgikopoulou, K; Roussaki, M; Borsari, C; Fotopoulou, T; Santarém, N; Barrias, E; Tejera Nevado, P; Hachenberg, J

A library of seventeen novel ether phospholipid analogues, containing 5-membered heterocyclic rings (1,2,3-triazolyl, isoxazolyl, 1,3,4-oxadiazolyl and 1,2,4-oxadiazolyl) in the lipid portion were designed and synthesized aiming to identify optimised miltefosine analogues. The compounds were evaluated for their in vitro antiparasitic activity against Leishmania infantum and Leishmania donovani intracellular ama...

Date: 2021   |   Origin: Repositório Aberto da Universidade do Porto
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