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Cardiotoxicity in haematological diseases : are the tyrosine kinase inhibitors ...

Francisco, A. R. Gaspar Lopes; Alves, D.; Gonçalves, I. S.; Menezes, M. N.; Silva, G. Lima da; Guimarães, T.; David, C.; Braga, J.; Guerra, L.

Introduction: Chemotherapy-induced cardiotoxicity is a growing concern. The true cardiotoxic impact of new drugs such as tyrosine kinase inhibitors is unknown, especially the ones used for chronic myeloid leukaemia. We aim to evaluate nilotinib and imatinib induced cardiotoxicity. Methods: Single-center prospective study of consecutive patients with chronic myeloid leukaemia treated with tyrosine kinase inhibit...


Transcatheter aortic valve implantation: efficacy, safety and mortality at 30-­...

Silva, P. Canas da; Francisco, A. R. Gaspar Lopes; Ferreira, P. Carrilho; Nobre, A.; Teles, R. Campante; Ribeiro, V. Gama; Patrício, L.; Silva, J. C.

Background: Transcatheter aortic valve implantation (TAVI) is currently an established therapy in patients with symptomatic severe aortic stenosis who are deemed inoperable or of very high surgical risk. Large population registries provide invaluable real world data. Purpose: To analyse the 30 days to 1­year results of all TAVI procedures performed throughout 8 years in an entire country. Methods: Nationwide TA...


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