6 documents found, page 1 of 1

Image-based in vitro screening reveals the trypanostatic activity of hydroxymet...

Immunological profile of resistance and susceptibility innaturally infected dog...

Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is as...

Estresse oxidativo, defesas antioxidantes e processo inflamatório na fase aguda...

Neste trabalho foram avaliados marcadores de estresse oxidativo (substâncias reativas de ácido tiobarbitúrico, proteína carbonilada e nitrito + nitrato), defesas antioxidantes (superóxido dismutase e glutationa total), parasitemia e processo inflamatório hepático, cardíaco e muscular em animais infectados pela cepa Y do Trypanosoma cruzi ou não e submetidos ou não ao tratamento com Benzonidazol, à alterações no...

Trypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infe...

Desferrioxamine (DFO) is a potent iron chelator that is also known to modulate inflammation and act as an efficient antioxidant under normal conditions and under oxidative stress. Many in vitro and in vivo studies have shown the efficacy of DFO in the treatment of viral, bacterial and protozoan infections. DFO is known to reduce the intensity of Trypanosoma cruzi infections in mice even during a course of thera...

Trypanosoma cruzi : effect of benznidazole therapy combined with the iron chela...

Iron chelators have been employed in various studies aimed at evaluating the relationship between the iron status of the host and the development of infection. In the present study, the effects of benznidazole (BZ) therapy in combination with the iron chelator desferrioxamine (DFO) on the development of infection in mice inoculated with Trypanosoma cruzi Y strain have been investigated. Infected mice treated wi...

Trypanosoma cruzi : serum levels of nitric oxide and expression of inducible ni...

The par tic i pa tion of nitric oxide (NO) in the con trol of blood par a si te mia and par a sit ism dur ing the acute phase of infec tion in dogs inoc u lated with blood try pom astig otes ( BT) or meta cy clic try pom astig otes (MT group) of Bere nice -78 Try pan o soma cru zi strain has been eval u ated. Ani mals of the MT group (n = 4) pre sented increased lev els of serum NO through out the infec tion wh...