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Non-invasive derivation of instantaneous free-wave ratio from invasive coronary...

Oliveira, Catarina; Vilela, Marta; Silva Marques, João; Jorge, Claudia; Rodrigues, Tiago; Francisco, Ana Rita; Oliveira, Rita Marante de

Invasive coronary physiology is underused and carries risks/costs. Artificial Intelligence (AI) might enable non-invasive physiology from invasive coronary angiography (CAG), possibly outperforming humans, but has seldom been explored, especially for instantaneous wave-free Ratio (iFR). We aimed to develop binary iFR lesion classification AI models and compare them with human performance. single-center retrospe...


Ultrasound Monitoring of Skeletal Muscle Wasting and Relation to Nutritional In...

Rosa Domingues, Catarina; Rodeia, Simão; Francisco, Ana Rita; Santos, Laura; Cerca, Carolina; Costa, Madalena; Pinto, Vera; Fortuna, Philip

Background: Critically ill patients frequently experience profound skeletal muscle (SM) wasting, to which early detection and effective clinical management remain significant challenges. Ultrasonography (US) provides early objective information about SM compared with usual functional tests. The characteristics of the optimal nutritional support are controversial. This observational study aimed to characterize t...


Coronary intravascular lithotripsy effectiveness and safety in a real-world cohort

Oliveira, Catarina; Vilela, Marta; Menezes, Miguel Nobre; Silva Marques, João; Jorge, Claudia; Rodrigues, Tiago; Almeida Duarte, José

Background: Coronary artery calcification is a predictor of adverse outcomes after percutaneous coronary intervention (PCI). Intravascular lithotripsy (IVL) is a promising tool for the treatment of calcified lesions. The aim of this study was to assess the effectiveness and safety of IVL. Methods: A single-center observational study of PCI procedure, with assessment of the outcomes of patients undergoing PCI us...


The sensitivity of DPD scintigraphy to detect transthyretin cardiac amyloidosis...

Coutinho, Maria Conceição Azevedo; Cortez-Dias, Nuno; Cantinho, Guilhermina; Gonçalves, Susana; Menezes, Miguel Nobre; Guimarães, Tatiana

Background: There is a growing need for a non-invasive test to detect cardiac involvement in patients with transthyretin-related hereditary amyloidosis (ATTR) caused by V30M mutation. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy is a promising method, but its accuracy in this particular mutation remains unknown. Methods: A cohort of 179 patients: 92 with early-onset disease (EoD, sympto...


The CTo-aBCDE score : a new predictor of success in chronic total occlusions

Rigueira, Joana; Aguiar-Ricardo, Inês; Menezes, Miguel Nobre; Santos, Rafael; Rodrigues, Tiago; Cunha, Nelson; Francisco, Ana Rita

Introduction: Patient selection for percutaneous coronary intervention (PCI) in chronic total occlusions (CTOs) is crucial to procedural success. Our aim was to identify independent predictors of success in CTO PCI in order to create an accurate score. Methods: In a single-center observational registry of CTO PCI, demographic and clinical data and anatomical characteristics of coronary lesions were recorded. Li...


Left ventricular systolic dysfunction in Marfan syndrome is related to aortic d...

Rigueira, Joana; Placido, R.; David, Cláudio; Rosario, Luis; Aguiar-Ricardo, Inês; Campos, P.; Francisco, Ana Rita; Pinto, Fausto J.; G. Almeida, Ana

Background: The cardiovascular involvement in Marfan syndrome (MS) is characterized mainly by dilatation and reduced distensibility of the ascending aorta. Left ventricular (LV) dysfunction has been detected in MS and a primary cardiomyopathy has been suggested but the pathophysiology is unclear. The purpose of this study was to evaluate the LV function in patients with MS and to assess the relationship with th...


Atrial fibrillation ablation : the added value of adenosine test in confirming ...

Nunes-Ferreira, Afonso; R. Agostinho, João; Cortez-Dias, Nuno; Silva, G. Lima da; Francisco, Ana Rita; Guimarães, T.; Gonçalves, I. Santos

Introduction: Adenosine test has been increasingly used to confirm pulmonary vein isolation (PVI) in patients undergoing ablation of atrial fibrillation (AF). However, its impact on the success of ablation remains unknown. Purposes: To evaluate the results of the adenosine triphosphate (ATP) test in patients undergoing PVI and assess the success of ablation related to the use of this test (adenosine-guided PVI ...


Port-a-cath catheter embolization to distal pulmonary artery branches : two tai...

Francisco, Ana Rita; Duarte, José A.; Oliveira, Eduardo Infante de

Several types of intravascular devices and catheters are frequently used for long-term drug therapy, especially for oncological patients. As a result, complications are becoming increasingly common, namely catheter embolization. Retrieving these devices is important, as embolized fragments may lead to serious consequences, such as arrhythmias, myocardial injury, thrombosis, infection, and even perforation and d...


Efficacy and safety of percutaneous left atrial appendage closure in chronic ki...

Vieira, Miguel Bigotte; Menezes, Miguel Nobre; Francisco, Ana Rita; Jorge, Cláudia; Carrilho-Ferreira, Pedro; Carpinteiro, Luís

INTRODUCTION AND AIMS: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, the most devastating complication being thromboembolism leading to fatal or disabling stroke. Although oral anticoagulation (OAC) is the mainstay of prevention therapy in the general population, its benefit in chronic kidney disease (CKD) patients is less well defined. End-stage renal disease patients treated with v...


Progression of myocardial sympathetic denervation assessed by 123I-MIBG imaging...

Coutinho, Maria da Conceição Azevedo; Dias, Nuno Cortez; Cantinho, Guilhermina; Conceição, Isabel; Guimarães, Tatiana; Silva, Gustavo Lima da

Introduction: Familial amyloid polyneuropathy (FAP) is a rare disease caused by systemic deposition of amyloidogenic variants of the transthyretin (TTR) protein. The TTR-V30M mutation is caused by the substitution of valine by methionine at position 30 and mainly affects the peripheral and autonomic nervous systems. Cardiovascular manifestations are common and are due to autonomic denervation and to amyloid dep...


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