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Enhancing lactone biosynthesis in Ashbya gossypii: towards sustainable producti...

Costa, Carlos E.; Freitas, Luís; Francisco, Miguel Duarte Dias; Aguiar, Tatiana Quinta; Domingues, Lucília

Lactones are volatile organic compounds sourced from lipid metabolism, with diverse applications, especially fragrances and flavours, being naturally present in fruits such as strawberries and peaches. Traditional lactone production is attained by biotransformation of hydroxylated fatty acids, which relies on limited precursor resources, such as vegetable or fish oils. However, the filamentous fungus Ashbya gos...


Lipid production from non-detoxified lignocellulosic biomass hydrolysate by Ash...

Francisco, Miguel Duarte Dias; Aguiar, Tatiana Quinta; Domingues, Lucília; Abreu, Gabriel Ferreira; Marques, Susana; Gírio, Francisco

Single-cell oil production from renewable and abundant feedstocks offers a sustainable and ecofriendly alternative to fossil-fuels consumption, an issue that has gained more attention throughout the years and needs to be addressed in the following ones. Xylose-utilizing oleaginous A. gossypii strains have the ability to accumulate lipids using detoxified industrial wastes as feedstock. Their performance using n...


Shaping animal design: the role of Hoxd13 targets in the evolution of vertebrat...

Francisco, Miguel Duarte Dias

Durante este projeto, explorámos novas hipóteses nas áreas de Biologia do Desenvolvimento e Evolução, numa tentativa de explicar a transição anatómica que ocorreu entre as barbatanas dos peixes e os membros dos tetrápodes. Este processo envolveu uma redução da área dérmica das barbatanas (“finfold”), bem como uma expansão das estruturas ósseas distais. Assim, a nossa hipótese propõe que genes envolvidos na rede...


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