10 documents found, page 1 of 1
The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Br...
Francisco, Stephany; Martinho, Vera C.; Ferreira, Margarida; Reis, Andreia; Moura, Gabriela; Soares, Ana Raquel; Santos, Manuel A. S.Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...
The role of MicroRNAs in proteostasis decline and protein aggregation during br...
Francisco, Stephany; Martinho, Vera; Ferreira, Margarida; Reis, Andreia; Moura, Gabriela; Soares, Ana Raquel; Santos Manuel A. S.Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...
Integration of segmented regression analysis with weighted gene correlation net...
Ferreira, Margarida; Francisco, Stephany; Soares, Ana R.; Nobre, Ana; Pinheiro, Miguel; Reis, Andreia; Neto, Sonya; Rodrigues, Ana João; Sousa, NunoGene expression alterations occurring with aging have been described for a multitude of species, organs, and cell types. However, most of the underlying studies rely on static comparisons of mean gene expression levels between age groups and do not account for the dynamics of gene expression throughout the lifespan. These studies also tend to disregard the pairwise relationships between gene expression profiles...
Quantitative proteomic profiling of agerelated protein aggregation in the healt...
Francisco, Stephany; Santos, Manuel; Soares, Ana RaquelThe aging process is a major risk factor for the development of several diseases especially neurodegenerative and metabolic disorders. As cells age, their ability to maintain protein homeostasis (proteostasis) progressively declines, leading to the accumulation of misfolded insoluble proteins, a phenomenon known as protein aggregation. The formation of insoluble protein aggregates has been established as a biol...
Proteomic analysis of tissue-specific protein aggregation signatures throughout...
Francisco, Stephany; Nobre, Ana; Ferreira, Margarida; Santa, Cátia; Anjo, Sandra; Manadas, Bruno; Santos, Manuel; Soares, AnaProteome and proteostasis network ( disruptions lead to proteostasis imbalances and accumulation of protein aggregates, characteristic of several age related diseases 1 3 The consequences of PN disturbances in the context of healthy aging remains to be thoroughly studied in mammals To determine whether accumulation of insoluble proteins occurs during mammalian aging, young adult 6 month old), middle aged 13 mon...
Does proteostasis get lost in translation? Implications for protein aggregation...
Francisco, Stephany; Ferreira, Margarida; Moura, Gabriela; Soares, Ana Raquel; Santos, Manuel A. S.Protein aggregation is a phenomenon of major relevance in neurodegenerative and neuromuscular disorders, cataracts, diabetes and many other diseases. Research has unveiled that proteins also aggregate in multiple tissues during healthy aging yet, the biological and biomedical relevance of this apparently asymptomatic phenomenon remains to be understood. It is known that proteome homeostasis (proteostasis) is ma...
Widespread protein aggregation across the mouse lifespan
Martins, Filipa; Francisco, Stephany; Sousa, Jéssica; Pereira, Cátia D.; Correia, Liliana; Camões, Fátima; Helguero, Luísa; Soares, Ana RaquelAging is characterized by a gradual decline in overall organismal fitness across the lifespan, and greatly enhances the risk for chronic diseases, as neuropathological disorders, diabetes, cancer and cardiovascular diseases. One of the hallmarks of aging is the loss of proteostasis, a regulated process responsible for maintaining the cellular proteome. When proteostasis is altered, proteome and proteostasis net...
Characterization of widespread proteome aggregation through aging in mammals
Francisco, Stephany; Nobre, Ana; Santa, Cátia; Martins, Filipa; Camões, Fátima; Rebelo, Sandra; Manadas, Bruno; Santos, Manuel; Soares, AnaProteome and proteostasis network disruptions accompany proteostasis alterations, leading to accumulation of protein aggregates, characteristic of several age-related diseases. Previous work in Caenorhabditis elegans and zebrafish unveiled asymptomatic protein aggregation (ARPA), characterized by generalized increased accumulation of insoluble proteins through aging. However, the consequences of protein homeost...
Evaluation of proteostasis across mammalian lifespan
Martins, Filipa; Francisco, Stephany; Sousa, Jéssica; Pereira, Cátia D.; Correia, Liliana; Camões, Fátima; Soares, Ana Raquel; Rebelo, SandraProteostasis is a highly regulated process involving the proteostasis network responsible for maintaining the cellular proteome. When proteostasis is altered, proteome and proteostasis network disruptions occur, leading to accumulation of protein aggregates, characteristic of several age-related diseases. Previous work performed in Caenorhabditis elegans and zebrafish unveiled asymptomatic protein aggregation (...
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and hum...
Pereira, Marisa; Francisco, Stephany; Varanda, Ana Sofia; Santos, Mafalda; Santos, Manuel A. S.; Soares, Ana RaquelTransfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these modifications increases the level of missense errors and affects codon decoding rate, contributing...