10 documents found, page 1 of 1

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts

Messenger RNA (mRNA)-based therapies offer enhanced control over the production of therapeutic proteins for many diseases. Their clinical implementation warrants formulations capable of delivering them safely and effectively to target sites. Owing to their chemical versatility, polymeric nanoparticles can be designed by combinatorial synthesis of different ionizable, cationic, and aromatic moieties to modulate ...

Induced pluripotent stem cell-derived vascular networks to screen nano-bio inte...

This work was funded by FEDER through the Program COMPETE and by Portuguese fund through FCT in context of the projects PTDC/SAU-TOX/121887/2010, POCI-01-0145-FEDER-029229, POCI-01-0145-FEDER-016390 and POCI-01-0145-FEDER-029414, as well as the European project ERAatUC (ref. 669088). PRP wishes to thank FCT for a BD fellowship (SFRH/BD/71042/2010). The iMM Fish Facility was supported by CONGENTO LISBOA-01-0145-...

High-throughput screening of nanoparticles in drug delivery

The use of pharmacologically active compounds to manage and treat diseases is of utmost relevance in clinical practice. It is well recognized that spatial-temporal control over the delivery of these biomolecules will greatly impact their pharmacokinetic profile and ultimately their therapeutic effect. Nanoparticles (NPs) prepared from different materials have been tested successfully in the clinic for the deliv...

Induced pluripotent stem cell-derived vascular networks to screen nano-bio inte...

The vascular bioactivity/safety of nanomaterials is typically evaluated by animal testing, which is of low throughput and does not account for biological differences between animals and humans such as ageing, metabolism and disease profiles. The development of personalized human in vitro platforms to evaluate the interaction of nanomaterials with the vascular system would be important for both therapeutic and r...

A light-triggerable formulation to control the stability of pro-angiogenic tran...

A high-throughput screening platform to identify nanocarriers for efficient del...

A near infrared light-triggerable modular formulation for the delivery of small...

Background: Externally triggered drug delivery systems hold considerable promise for improving the treatment of many diseases, in particular, diseases where the spatial-temporal release of the drug is critical to maximize their biological effect whilst minimizing undesirable, off-target, side effects. Results: Herein, we developed a light-triggerable formulation that takes advantage of hostguest chemistry to co...

Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Deli...

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Bioconjugate Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.bioconjchem.7b00820; The authors would like to thank the financial support of FEDER through the program COM...

Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide

The reaction kinetics for the acid nitrosation of formamidine disulfide (FDS) show an autocatalytic behavior that arises from the fact that the thiocyanate ion formed as a product acts as a powerful catalyst for the nitrosation reaction. In the presence of added nucleophiles the suppression of the autocatalytic route results from competition for the nitrous acid between the added halides and the thiocyanate ani...

Variações sazonais da composição química e índice de condição da amêijoa-boa, R...

A nível nacional, por reunir as condições mais propícias para a reprodução e desenvolvimento da amêjoa-boa (Ruditapes decussatus), a Ria Formosa constitui o mais importante centro de exploração desta espécie de elevado valor comercial, representando cerca de 80% das amêijoas comercializadas em Portugal. O cultivo é realizado em viveiros, explorados por mariscadores, organizados em associações. Uma estimativa co...