17 documents found, page 1 of 2
Antibacterial properties of photo-crosslinked chitosan/methacrylated hyaluronic...
Gonçalves, Raquel R.; Peixoto, Daniela; Costa, Rui R.; Franco, Albina Ribeiro; Castro, Vânia I. B.; Pires, R. A.; Reis, R. L.; Pashkuleva, I.The current treatments for wounds often fail to produce adequate healing, leaving wounds vulnerable to persistent infections and development of drug-resistant microbial biofilms. New natural-derived nanoparticles were studied to impair bacteria colonization and hinder the formation of biofilms in wounds. The nanoparticles were fabricated through polyelectrolyte complexation of chitosan (CS, polycation) and hyal...
Chitosan-based hierarchical scaffolds crosslinked with genipin
Piaia, Lya; Silva, Simone S.; Fernandes, Emanuel Mouta; Gomes, Joana M.; Franco, Albina Ribeiro; Leonor, I. B.; Fredel, Márcio C.; Salmoria, Gean V.Osteochondral defects present significant challenges for effective tissue regeneration due to the complex composition of bone and cartilage. To address this challenge, this study presents the fabrication of hierarchical scaffolds combining chitosan/β-tricalcium phosphate (β-TCP) to simulate a bone-like layer, interconnected with a silk fibroin layer to mimic cartilage, thus replicating the cartilage-like laye...
Hydroxyapatite/alginate/gellan gum inks with osteoconduction and osteogenic pot...
Bastos, Ana Raquel Fernandes; da Silva, Lucília Pereira; Maia, F. Raquel; Franco, Albina Ribeiro; Noro, Jennifer Martins; Silva, CarlaThere is a growing demand for engineered bone tissues custom-designed to match the patient-specific defect size and in vitro models for studying bone diseases and/or drug screening. Herein, we propose a bioprinted bone tissue construct using SaOs-2 cells within alginate/gellan gum/hydroxyapatite inks. Different ink formulations were developed with varying hydroxyapatite content and then evaluated for viscoelast...
Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue eng...
Piaia, Lya; Silva, Simone S.; Gomes, Joana M.; Franco, Albina Ribeiro; Fernandes, Emanuel Mouta; Lobo, Flávia Cristina Marques; Rodrigues, Luísa C.Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable...
Development and characterization of highly stable silver nanoparticles as novel...
Massironi, Alessio; Franco, Albina Ribeiro; Babo, Pedro Miguel Sousa; Puppi, Dario; Chiellini, Federica; Reis, R. L.; Gomes, Manuela E.Recurrent microbial infections are a major cause of surgical failure and morbidity. Wound healing strategies based on hydrogels have been proposed to provide at once a barrier against pathogen microbial colonization, as well as a favorable environment for tissue repair. Nevertheless, most biocompatible hydrogel materials are more bacteriostatic than antimicrobial materials, and lack specific action against path...
Untangling the biological and inflammatory behavior of silk-like sutures In vivo
Franco, Albina Ribeiro; Pirraco, Rogério P.; Fernandes, Emanuel Mouta; Rodrigues, Fernando; Leonor, I. B.; Kaplan, David L.; Reis, R. L.Recombinant spider silk materials with antimicrobial peptides are a promising new class of drug-free antimicrobial materials capable of preventing surgical site infections (SSI), but their potential to impede infections is unclear. Herein, we aimed to unravel the biological and inflammatory potential of bioengineered spider silk materials to prevent SSI using an infection animal model. Silk-like fibers made of ...
A graded, porous composite of natural biopolymers and octacalcium phosphate gui...
Amann, Elisabeth; Amirall, Amisel; Franco, Albina Ribeiro; Poh, Patrina S. P.; Sola Dueñas, Francisco J.; Fuentes Estévez, Gastón; Leonor, I. B.Lesions involving the osteochondral unit are difficult to treat. Biomimetic scaffolds are previously shown as promising alternative. Such devices often lack multiple functional layers that mimic bone, cartilage, and the interface. In this study, multilayered scaffolds are developed based on the use of natural extracellular matrix (ECM)â like biopolymers. Particular attention is paid to obtain a complex matrix t...
An overview of the antimicrobial properties of lignocellulosic materials
Lobo, Flávia Cristina Marques; Franco, Albina Ribeiro; Fernandes, Emanuel Mouta; Reis, R. L.Pathogenic microbes are a major source of health and environmental problems, mostly due to their easy proliferation on most surfaces. Currently, new classes of antimicrobial agents are under development to prevent microbial adhesion and biofilm formation. However, they are mostly from synthetic origin and present several disadvantages. The use of natural biopolymers such as cellulose, hemicellulose, and lignin,...
Toward spinning greener advanced silk fibers by feeding silkworms with nanomate...
Ramos, Nuno; Miranda, Margarida S.; Franco, Albina Ribeiro; Silva, Simone S.; Azevedo, Jorge; Dias, Isabel R.; Reis, R. L.; Viegas, CarlosSilk has been used in several biomedical applications, including tissue engineering, drug delivery systems, biomedical implants, and diagnostic medical devices, due to its attractive intrinsic properties such as biocompatibility, controllable biodegradability, and excellent mechanical properties. In recent years, several attempts have been made to produce silk fibers with improved properties and new functionali...
The effects of platelet lysate patches on the activity of tendon-derived cells
Almeida, Raquel Carvalho Ferreira Costa; Franco, Albina Ribeiro; Pesqueira, Tamagno; Oliveira, Mariana Braga; Babo, Pedro S.; Leonor, I. B.; Mano, J. F.Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeuti...