14 documents found, page 1 of 2
Acute Symptomatic Seizures in Patients with Recurrent Ischemic Stroke: A Multic...
Leal Rato, Miguel; Schön, Miguel; Zafra, Maria Paula; Aguiar de Sousa, Diana; Pinho E Melo, Teresa; Franco, Ana Catarina; Peralta, Ana RitaObjective: Epileptic seizures occur frequently after stroke due to changes in brain function and structure, and up to around 10% of stroke patients experience stroke recurrence in the first year. We aimed to establish the risk of acute symptomatic seizures in patients with recurrent stroke. Methods: Retrospective cohort study including consecutive admissions to a Stroke Unit due to acute ischemic stroke, during...
Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome
Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Leal, Ana; Botelho, Mariana; Carmo-Silva, Sara; Águas, Rodolfo; Cortes, LuísaHutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal genetic condition that arises from a single nucleotide alteration in the LMNA gene, leading to the production of a defective lamin A protein known as progerin. The accumulation of progerin accelerates the onset of a dramatic premature aging phenotype in children with HGPS, characterized by low body weight, lipodystrophy, metabolic dysfunction, skin...
Histopathological characterization of cerebral small vessel disease in epilepsy...
Coelho, Pedro; Madureira, João; Franco, Ana Catarina; Peralta, Ana; Bentes, Carla; Rainha Campos, Alexandre; Anink, Jasper; Aronica, EleonoraBackground: Cerebrovascular disease (CVD) is a major contributor to epilepsy; however, patients with epilepsy also have a significantly increased risk of stroke. The way in which epilepsy contributes to the increased risk of stroke is still uncertain and is ill-characterized in neuropathological studies. A neuropathological characterization of cerebral small vessel disease (cSVD) in patients with chronic epilep...
Skin senescence: mechanisms and impact on whole-body aging
Franco, Ana Catarina; Aveleira, Célia A.; Cavadas, CláudiaThe skin is the largest organ and has a key protective role. Similar to any other tissue, the skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging, triggered by environmental factors that contribute to accelerating the skin aging process. Aged skin shows structural, cellular, and molecular changes and accumulation of senescent cells. These senescent cells can induce or accel...
Stereo-EEG recording and minimally invasive treatment of a periventricular nodu...
Franco, Ana Catarina; Peralta, Ana Rita; Morgado, Carlos; Gonçalves Ferreira, António; Rainha Campos, Alexandre; Bentes, CarlaPeriventricular nodular heterotopias (PNHs) are malformations of cortical development. These are frequently associated with drug-resistant epilepsy. Stereo-electroencephalography (SEEG) is usually part of the epilepsy pre-surgical evaluation in order to find the epileptogenic zone (EZ). SEEG-guided radiofrequency-thermocoagulation (RF-TC) has been used to ablate or disrupt the EZ and proved to be effective, wit...
Syncope due to ictal asystole : a challenging semiology
Leal Rato, Miguel; Ionel, Cristina; Baduro, Yanina; Oliveira, Renato; Franco, Ana Catarina; Peralta, Ana Rita; Bentes, CarlaCardiac rhythm abnormalities are a possibly serious manifestation of epilepsy and seizures. We present a 36-year-old woman with episodes of altered mental status and loss of muscle tone for 20-30 seconds, preceded by déjà vu, bilateral tinnitus and generalized coldness.
Anti-glutamic acid decarboxylase encephalitis presenting with choreo‐dystonic m...
Azevedo Kauppila, Linda; Coelho, Miguel; Franco, Ana Catarina; Teodoro, Tiago; Peralta, Ana Rita; Bentes, Carla; Falcão, Filipa; Albuquerque, LuísaGlutamic acid decarboxylase (GAD) antibodies (ab) have been associated with rare disorders, such as Stiff-person syndrome, limbic encephalitis, cerebellar ataxia, and temporal lobe epilepsy. Other systemic autoimmune disorders have been linked to antiGAD ab, among them, diabetes mellitus (DM).
Personality patterns of people with medically refractory epilepsy : does the ep...
Novais, Filipa; Franco, Ana Catarina; Loureiro, Susana; Andrea, Mafalda; Figueira, Maria Luísa; Pimentel, José; Pestana, Luís CâmaraObjectives: The aims of this study were to determine the rate of dysfunctional personality patterns before and after epilepsy surgery, their types, and the importance of the epileptogenic zone in a sample of people with refractory epilepsy. Methods: We conducted an ambispective observational study, including refractory epilepsy surgery candidates. Demographic, psychiatric, and neurological data were recorded. E...
Early EEG predicts poststroke epilepsy
Bentes, Carla; Martins, Hugo; Peralta, Ana Rita; Morgado, Carlos; Casimiro, Carlos; Franco, Ana Catarina; Fonseca, Ana Catarina; Geraldes, RuthObjective: Electroencephalography (EEG) can identify biomarkers of epileptogenesis and ictogenesis. However, few studies have used EEG in the prediction of poststroke seizures. Our primary aim was to evaluate whether early EEG abnormalities can predict poststroke epilepsy. Methods: A prospective study of consecutive acute anterior circulation ischemic stroke patients, without previous epileptic seizures, who we...
Quantitative EEG and functional outcome following acute ischemic stroke
Bentes, Carla; Peralta, Ana; Viana, Pedro; Martins, Hugo F G; Morgado, Carlos; Casimiro, Carlos; Franco, Ana Catarina; Fonseca, Ana CatarinaObjective: To identify the most accurate quantitative electroencephalographic (qEEG) predictor(s) of unfavorable post-ischemic stroke outcome, and its discriminative capacity compared to already known demographic, clinical and imaging prognostic markers. Methods: Prospective cohort of 151 consecutive anterior circulation ischemic stroke patients followed for 12 months. EEG was recorded within 72 h and at discha...