45 documents found, page 1 of 5
UHPLC-MS/MS methodology for analysis of new synthetic opioids and hallucinogens...
Pereira, Joana; Antunes, Mónica; Neng, N.R.; Mustra, Carla; Franco, João; Fonseca, SuzanaBackground & Aims: New Psychoactive Substances (NPS) are a real contemporaneous threat, due to their potency, dangerousness, and lack of control/monitoring. The NPS group that has grown the most is the synthetic opioids group, where fentanyl and its analogues stand out. However, the emerging concerning synthetic opioids are nitazenes. Due to their high potency, even minimal consumption doses can lead to severe ...
Toxicologia Forense: métodos analíticos para a determinação de Α-PHP e Α-PIHP
Dinis, Pedro; Franco, João; Margalho, CláudiaA análise mais recente do Observatório Europeu da Droga e da Toxicodependência (EMCDDA), o Relatório Europeu sobre Drogas de 2024, revela um mercado resiliente e influenciado pelos desenvolvimentos globais. Os problemas persistentes de saúde e segurança colocados tanto por drogas ilícitas tradicionais quanto por substâncias mais recentes criam um ambiente desafiador para a elaboração e implementação de resposta...
Comprehensive toxicological analysis in a case of unexpected fatal codeine into...
Margalho, Cláudia; Emanuel Santos Pinheiro, João; Dinis, Pedro; Mendonça, Ricardo; Castanheira, Alice; Franco, JoãoBackground and Aims: Codeine, a commonly prescribed opioid analgesic and antitussive, is widely used either alone or in combination with other medications. This substance is typically administered orally and is well absorbed from the gastrointestinal tract. After being absorbed, it is distributed throughout the body and crosses the blood-brain barrier to reach the central nervous system, where it exerts its pha...
Α-Pyrrolidinoisohexanophenone (Α-PIHP) in three fatal
Dinis, Pedro; Machado, Francisca; Franco, João; Margalho, CláudiaBackground & Aims The New Psychoactive Substances (NPSs) are widely spread worldwide through the illicit markets and are increasingly the cause of intoxication deaths. Alpha-pyrrolidinoisohexanophenone (α-PiHP) is a positional isomer of α-pyrrolidinohexanophenone (α-PHP) and has been reported for the first time in 2016 at seized materials in China. Both substances are pyrovalerone derivatives from the synthetic...
α-Pyrrolidinohexanophenone (α-PHP) and α-Pyrrolidinoisohexanophenone (α-PiHP): ...
Dinis, Pedro; Franco, João; Margalho, CláudiaNew Psychoactive Substances are currently a serious and growing problem affecting public health worldwide. By 2022, 1184 of these substances had been identified over a period of 16 years. Within these, α-pyrrolidinohexanophenone (α-PHP) and α-pyrrolidinoisohexanophenone (α-PiHP) have emerged, two synthetic cathinones from the pyrovalerone derivates subgroup that are positional isomers of each other. Alpha-PHP a...
Detection and quantification of selected cannabinoids in oral fluid samples by ...
Antunes, Mónica; Simões, Susana; Fonseca, Suzana; Franco, João; Gallardo, Eugenia; Barroso, MárioCannabis is the most widely consumed illicit drug worldwide. As consumption rates increase, partially due to the decriminalization of its use for medicinal and recreational purposes, analytical methods for monitoring different cannabinoids in several biological matrices have been developed. Herein, a simple and fast extraction procedure to extract natural cannabinoids from oral fluid (OF) samples was developed ...
LC–MS-MS-MS3 for the determination and quantification of ∆9-tetrahydrocannabino...
Proença, Paula; Teixeira, Helena; Martinho, Beatriz; Monteiro, Carla; Franco, João; Corte-Real, FranciscoDue to the high prevalence of cannabinoids in forensic toxicology analysis, it is crucial to have an efficient method that allows the use of a small sample amount and that requires a minimal sample preparation for the determination and quantification of low concentrations. A simple, highly selective and high throughput liquid chromatography–tandem mass spectrometry methodology (LC–MS-MS-MS3) was developed for t...
Desenvolvimento e validação de um método analítico para a determinação de canab...
Antunes, Mónica; Simões, Susana; Fonseca, Suzana; Franco, João; Gallardo, Eugenia; Barroso, MárioA canábis é a droga de abuso mais consumida na Europa, pelo que várias metodologias analíticas têm sido desenvolvidas para a quantificação dos seus componentes em matrizes biológicas, especialmente sangue e urina. No entanto, cada vez mais se está a reconhecer a importância do estudo de matrizes biológicas não-convencionais, nomeadamente cabelo e fluido oral (ou saliva) – os seus procedimentos de recolha não sã...
Análise toxicológica forense a amostras não biológicas e cabelo: investigando a...
Margalho, Cláudia; Barroso, Mário; Franco, JoãoA análise toxicológica forense é uma ferramenta fundamental no auxilio da investigação de casos complexos através da identificação de substâncias tóxicas presentes nas amostras relacionadas com essas investigações. Um cenário peculiar que pode requerer essa abordagem especializada é a investigação de um cadáver mumificado. A mumificação é um processo natural ou artificial que preserva o corpo de um cadáver, por...
Development and validation of a multi-substance method for routine analysis of ...
Matos, Francisco; Barroso, Mário; Antunes, Mónica; Franco, João; Fonseca, SuzanaPesticides play an important role in forensic toxicology and are usually classified as a single class of chemicals, but in fact there are several different types of compounds, including organophosphates, carbamates, pyrethroids or organochlorines, among others, with different toxicities. Pesticide analysis in post-mortem samples can be difficult due to the complexity of the samples and to the high toxicity of t...