8 documents found, page 1 of 1
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, N; Sousa, SR; Padrão, T; Carvalho, A; Lucas, R; Canadas, RF; Lavrador, C; Alexandre, N; Gärtner, F; Monteiro, FJ; Gutierres, MThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
Local Antibiotic Delivery Ceramic Bone Substitutes for the Treatment of Infecte...
Alegrete, N; Sousa, SR; Peleteiro, B; Monteiro, FJ; Gutierres, MAims: the focus of this study is to evaluate if the combination of an antibiotic with a ceramic biomaterial is effective in treating osteomyelitis in an infected animal model and to define which model and protocol are best suited for in vivo experiments of local bone infection treatment. Methods: a systematic review was carried out based on PRISMA statement guidelines. A PubMed search was conducted to find orig...
Mechanobiology of Colorectal Cancer
Brás, MM; Sousa, SR; Carneiro, F; Radmacher, M; Granja, PLIn this review, the mechanobiology of colorectal cancer (CRC) are discussed. Mecha-notransduction of CRC is addressed considering the relationship of several biophysical cues and biochemical pathways. Mechanobiology is focused on considering how it may influence epithelial cells in terms of motility, morphometric changes, intravasation, circulation, extravasation, and metastization in CRC development. The roles...
Gastrointestinal parasitism in Miranda donkeys : epidemiology and selective con...
Sousa, SR; Anastácio, S.; Novoa, Miguel; Paz-Silva, Adolfo; Madeira de Carvalho, LuísIn Portugal, equine parasitism in pasture animals is characterized by high parasitic burden and high helminthic biodiversity; both factors are potentially pathogenic for their hosts. The decrease in the number of donkeys over the last years in Portugal, their importance in rural lowland and mountain ecosystems and pastures and the scarce information regarding their parasitism led to this research, which aimed t...
Melanoma in the Eyes of Mechanobiology
Brás, MM; Radmacher, M; Sousa, SR; Granja, PLSkin is the largest organ of the human body with several important functions that can be impaired by injury, genetic or chronic diseases. Among all skin diseases, melanoma is one of the most severe, which can lead to death, due to metastization. Mechanotransduction has a crucial role for motility, invasion, adhesion and metastization processes, since it deals with the response of cells to physical forces. Signa...
The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite ...
Coelho, CC; Padrão, T; Costa, L; Pinto, MT; Costa, PC; Domingues, VF; Quadros, PA; Monteiro, FJ; Sousa, SRBone graft infections are serious complications in orthopaedics and the growing resistance to antibiotics is increasing the need for antibacterial strategies. The use of magnesium oxide (MgO) is an interesting alternative since it possesses broad-spectrum antibacterial activity. Additionally, magnesium ions also play a role in bone regeneration, which makes MgO more appealing than other metal oxides. Therefore,...
Influence of PLLA/PCL/HA scaffold fiber orientation on mechanical properties an...
de, Siqueira, L; Ribeiro, N; Paredes, MBA; Grenho, L; Cunha-Reis, C; Trichês, ES; Fernandes, MH; Sousa, SR; Monteiro, FJScaffolds based on aligned and non-aligned poly (L-lactic acid) (PLLA)/polycaprolactone (PCL) fibers obtained by electrospinning, associated to electrosprayed hydroxyapatite (HA) for tissue engineering applications were developed and their performance was compared in terms of their morphology and biological and mechanical behaviors. The morphological results assessed by scanning electron microscopy showed a mes...
Fibrin functionalization with synthetic adhesive ligands interacting with a6ß1 ...
Silva, J; Bento, AR; Barros, D; Laundos, TL; Sousa, SR; Quelhas, P; Sousa, MM; Pêgo, AP; Amaral, IFTo enhance fibrin hydrogel affinity towards pluripotent stem cell-derived neural stem/progenitor cells (NSPCs) and its capacity to support NSPC migration and neurite extension, we explored the tethering of synthetic peptides engaging integrin a6ß1, a cell receptor enriched in NSPCs. Six a6ß1 integrin ligands were tested for their ability to support integrin a6ß1-mediated adhesion of embryonic stem cell-derived ...