5 documents found, page 1 of 1
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation
Richter, Gesa M; Kruppa, Jochen; Keceli, H Gencay; Ataman-Duruel, Emel Tuğba; Graetz, Christian; Pischon, Nicole; Wagner, Gunar; Rendenbach, CarstenBackground: In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The ...
Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of ...
Geritz, Johanna; Maetzold, Sara; Steffen, Maren; Pilotto, Andrea; Corrà, Marta; Moscovich, Mariana; Rizzetti, Maria C; Borroni, BarbaraBackground: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits,...
Motor, cognitive and mobility deficits in 1000 geriatric patients : protocol of...
Geritz, Johanna; Maetzold, Sara; Steffen, Maren; Pilotto, Andrea; Corrà, Marta F.; Moscovich, Mariana; Rizzetti, Maria C.; Borroni, BarbaraBackground: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits,...
A combined epigenome- and transcriptome-wide association study of the oral mast...
Richter, Gesa M.; Kruppa, Jochen; Munz, Matthias; Wiehe, Ricarda; Häsler, Robert; Franke, Andre; Martins, Orlando; Jockel-Schneider, YvonneBackground: The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to id...
Genome-wide association analyses identify new risk variants and the genetic arc...
van Rheenen, Wouter; Shatunov, Aleksey; Dekker, Annelot M.; McLaughlin, Russell L.; Diekstra, Frank P.; Pulit, Sara L.; van der Spek, Rick A. A.To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fin...