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Concordance between FVC and FEV<sub>6</sub> for identifying chronic airflow obs...

Knox-Brown, Ben; Potts, James; Franssen, Frits M. E.; Nielsen, Rune; Denguezli, Meriem; Rotevatn, Anders Ørskov; Juvekar, Sanjay K.

Introduction: We investigated whether the forced expiratory volume in 6 s (FEV6) can be used as a surrogate for the forced vital capacity (FVC). Methods: The Burden of Obstructive Lung Disease is a multinational cohort study. At baseline, data were collected from adults aged 40 years or older, from 41 sites across 34 countries. Participants from 18 sites were followed up after a median of 8.3 years. Participant...


Effects of ActiGraph's filter, epoch length and non-wearing time algorithm on s...

Antão, Joana; Rebelo, Patrícia; Almeida, Sara; Franssen, Frits M. E.; Spruit, Martijn A.; Marques, Alda

The influence of the ActiGraph® processing criteria on estimating step counts in chronic obstructive pulmonary disease (COPD) remains uncertain. This study aimed to assess the influence of filters, epoch lengths and non-wearing time (NWT) algorithms on steps/day in people with COPD. ActiGraph GT3X+ was worn on the waist for seven days. Steps were detected using different filters (normal and low-frequency extens...


Geographical variation in lung function: results from the multicentric cross-se...

Burney, Peter G. J.; Potts, James; Knox-Brown, Ben; Erhabor, Gregory; Hacene Cherkaski, Hamid; Mortimer, Kevin; Anand, Mahesh Padukudru

Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,...


Prevalence of chronic cough, its risk factors and population attributable risk ...

Abozid, Hazim; Patel, Jaymini; Burney, Peter; Hartl, Sylvia; Breyer-Kohansal, Robab; Mortimer, Kevin; Nafees, Asaad A.; Al Ghobain, Mohammed

Background: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a stan...


Demystification of artificial intelligence for respiratory clinicians managing ...

Antão, Joana; Mast, Jeroen de; Marques, Alda; Franssen, Frits M. E.; Spruit, Martijn A.; Deng, Qichen

Introduction Asthma and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide. Despite all available diagnostics and treatments, these conditions pose a significant individual, economic and social burden. Artificial intelligence (AI) promises to support clinical decision-making processes by optimizing diagnosis and treatment strategies of these heterogeneous and co...


Small airways obstruction and its risk factors in the Burden of Obstructive Lun...

Knox-Brown, Ben; Patel, Jaymini; Potts, James; Ahmed, Rana; Aquart-Stewart, Althea; Cherkaski, Hamid Hacene; Denguezli, Meriam; Elbiaze, Mohammed

Background: Small airways obstruction is a common feature of obstructive lung diseases. Research is scarce on small airways obstruction, its global prevalence, and risk factors. We aimed to estimate the prevalence of small airways obstruction, examine the associated risk factors, and compare the findings for two different spirometry parameters. Methods: The Burden of Obstructive Lung Disease study is a multinat...


Differences in pulmonary and extra-pulmonary traits between women and men with ...

Souto-Miranda, Sara; van ‘t Hul, Alex J.; Vaes, Anouk W.; Antons, Jeanine C.; Djamin, Remco S.; Janssen, Daisy J. A.; Franssen, Frits M. E.

Background: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown. Methods: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differe...


Report of an ad-hoc international task force to develop an expert-based opinion...

Spruit, Martijn A.; Holland, Anne E.; Singh, Sally J.; Troosters, Thierry; Balbi, Bruno; Berny, Sue; Brooks, Dina; Burtin, Chris; Clini, Enrico

No abstract available.


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