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Molecular characterization and virulence profile of Klebsiella pneumoniae and K...

Castro, Joana Isabel Reis; Oliveira, Ricardo; Fernandes, Liliana Sousa; Carvalho, Isabel; Oliveira, Hugo Alexandre Mendes; Brinks, Erik; Cho, Gyu-Sung

Klebsiella spp. are important pathogens of humans and companion animals such as cats and dogs, capable of causing severe life-threatening diseases. The aim of this study was to characterize the molecular and phenotypic properties of Klebsiella pneumoniae and Klebsiella oxytoca isolated from ill companion animals by whole genome sequencing, followed by in vitro assessment of biofilm formation and in vivo pathoge...


Multidrug-resistant Klebsiella pneumoniae and Klebsiella variicola isolated fro...

Castro, Joana; Araújo, Daniela Eira; Oliveira, Hugo Alexandre Mendes; Fernandes, Liliana Sousa; Oliveira, Ricardo; Brinks, Erick; Cho, Gyu-Sung

The emergence of antibiotic-resistant Klebsiella spp. has become a huge problem in clinical settings. In this study, we aimed to characterize the molecular and phenotypic features of 21 MDR Klebsiella isolates (n =19 of K. pneumoniae, and n =2 of K. variicola) isolated from patients admitted to two central hospitals in northern Portugal by using whole-genome sequencing (WGS), followed by an in vitro assessment ...


Genomic and phenotypic profiling of multidrugresistant Klebsiella pneumoniae an...

Castro, Joana Isabel Reis; Araújo, Daniela; Oliveira, Hugo Alexandre Mendes; Fernandes, Liliana Sousa; Oliveira, Ricardo; Cho, Gyu-Sung; Franz, Charles

With the alarming increase in antibiotic resistance and the global spread of resistance mechanisms, the emergence of antibiotic-resistant Klebsiella spp. has become a significant challenge in clinical settings. It is therefore important to monitor the characteristics of Klebsiella isolates in circulation to develop mitigation solutions. The aim of this study was to characterize the genetic and phenotypic charac...


Characterization of molecular features and virulence profile of Klebsiella pneu...

Araújo, Daniela; Castro, Joana Isabel Reis; Oliveira, Ricardo; Oliveira, Hugo Alexandre Mendes; Fernandes, Liliana Sousa; Carvalho, Isabel

Klebsiella spp. are important pathogens that affect both humans and animals and can cause serious life-threatening diseases. The increasing incidence of Klebsiella infections in companion animals (e.g., cats and dogs) can result in the death of animals and become a serious public health concern. The study of strains isolated from animal infections can be a means of assessing the risk of transmission to humans, ...


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