14 documents found, page 1 of 2
Mixed-valence pentadecavanadate with Ca2+-ATPase inhibition potential and anti-...
Brito, Bianca R.; Camilo, Heloísa de S.; Cruz, Anderson F. da; Ribeiro, Ronny R.; Sá, Eduardo L. de; Oliveira, Carolina Camargo de; Fraqueza, GilPolyoxovanadates are a subclass of polyoxometalates (POMs) known to interact with proteins and to present anticancer, antimicrobial, and antiviral activities. Herein, we aimed to pursue the study of the breast anticancer activity of a mixed-valence polyoxovanadate, [Cl@VV 7V IV 8O36] 6− (V15) against MCF-7 and MDA-MB-231 cancer cell lines and to analyze its Ca2+-ATPase inhibition potential. 51V NMR and UV-Vis/N...
Alimentos com história: histórias de alimentos
Cruz, Ana Lúcia; Quintas, Célia; Esteves, Eduardo; Fraqueza, Gil; Ratao, Isabel; Aníbal, Jaime; Melo, Jessie; Pereira, Jorge; Jesus, JoséA Dieta Mediterrânica é um património histórico ativo que depende da utilização sustentável de recursos, guiando-se pelos ritmos da natureza e pelo respeito pela biodiversidade. O conceito de Dieta Mediterrânica não compreende apenas a alimentação, todavia os aspetos relacionados com os hábitos alimentares, os alimentos e a sua preparação são marcadores da identidade coletiva de um povo. Assim, este modelo cult...
Repurposing therapeutic drugs complexed to Vanadium in Cancer
De Sousa-Coelho, Ana Luísa; Fraqueza, Gil; Aureliano, M.Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs,...
Inhibition of SERCA and PMCA Ca2+-ATPase activities by polyoxotungstates
Aureliano, Manuel; Fraqueza, Gil; Berrocal, Maria; Cordoba-Granados, Juan J.; Gumerova, Nadiia I.; Rompel, Annette; Gutierrez-Merino, CarlosPlasma membrane calcium ATPases (PMCA) and sarco(endo) reticulum calcium ATPases (SERCA) are key proteins in the maintenance of calcium homeostasis. Herein, we compare for the first time the inhibition of SERCA and PMCA calcium pumps by several polyoxotungstates (POTs), namely by Wells-Dawson phospho-tungstate anions [P2W18O62]6-(intact, {P2W18}), [P2W17O61]10-(monolacunary, {P2W17}), [P2W15O56]12-(trilacunary,...
Decavanadate and metformin-decavanadate effects in human melanoma cells
de Sousa-Coelho, Ana Luísa; Aureliano, Manuel; Fraqueza, Gil; Serrão, Gisela; Gonçalves, João; Sánchez-Lombardo, Irma; Link, Wolfgang; Ferreira, BibianaDecavanadate is a polyoxometalate (POMs) that has shown extensive biological activities, including antidiabetic and anticancer activity. Importantly, vanadium-based compounds as well as antidiabetic biguanide drugs, such as metformin, have shown to exert therapeutic effects in melanoma. A combination of these agents, the metformin-decavanadate complex, was also recognized for its antidiabetic effects and recent...
Reduction of carbon emissions in a mediterranean urban wastewater treatment plant
Silva, Manuela; Cristovão, Luís; Marinho, Duarte; Esteves, Eduardo; Fraqueza, Gil; Martins, AntónioIn the last few decades, with the rapid growth of population, and more than half of them living in cities, the urban wastewater treatment has become a big challenge that consumes many resources, namely energy. In a climate change scenario, the Mediterranean region is facing more frequent water scarcity periods, and urban water reuse can be a solution, at least for supplying some non-potable water uses. In this ...
The Ca2+-ATPase inhibition potential of gold (I, III) compounds
Fonseca, Custódia; Fraqueza, Gil; Carabineiro, Sónia A.; Aureliano, ManuelThe therapeutic applications of gold are well-known for many centuries. The most used gold compounds contain Au(I). Herein, we report, for the first time, the ability of four Au(I) and Au(III) complexes, namely dichloro (2-pyridinecarboxylate) Au(III) (abbreviated as1), chlorotrimethylphosphine Au(I) (2), 1,3-bis(2,6-diisopropylphenyl) imidazole-2-ylidene Au(I) chloride (3), and chlorotriphenylphosphine Au(I) (...
Inhibition of Na+/K+- and Ca2+-ATPase activities by phosphotetradecavanadate
Fraqueza, Gil; Fuentes, Juan; Krivosudský, Lukáš; Dutta, Saikat; Mal, Sib Sankar; Roller, Alexander; Giester, Gerald; Rompel, Annette; Aureliano, ManuelPolyoxometalates (POMs) are promising inorganic inhibitors for P-type ATPases. The experimental models used to study the effects of POMs on these ATPases are usually in vitro models using vesicles from several membrane sources. Very recently, some polyoxotungstates, such as the Dawson anion [P2W18O62]6-, were shown to be potent P-type ATPase inhibitors; being active in vitro as well as in ex-vivo. In the presen...
Polyoxovanadate inhibition of Escherichia coli growth shows a reverse correlati...
Marques-da-Silva, Dorinda; Fraqueza, Gil; Lagoa, Ricardo; Vannathan, Anjana Anandan; Mal, Sib Sankar; Aureliano, ManuelRecently, a global analysis of the structure-activity-relationship of a series of polyoxometalates (POMs) revealed that the most active POMs were ascribed to be polyoxovanadates (POVs), especially decavanadate (V-10), which was very active against certain bacteria (Bijelic et al., Chem. Commun., 2018). The present study explores this observation and compares the effects of three POVs namely MnV11, MnV13 and V-1...
The P-type ATPase inhibiting potential of polyoxotungstates.
Gumerova, Nadiia; Krivosudský, Lukáš; Fraqueza, Gil; Breibeck, Joscha; Al-Sayed, Emir; Tanuhadi, Elias; Bijelic, Aleksandar; Fuentes, JuanPolyoxometalates (POMs) are transition metal complexes that exhibit a broad diversity of structures and properties rendering them promising for biological purposes. POMs are able to inhibit a series of biologically important enzymes, including phosphatases, and thus are able to affect many biochemical processes. In the present study, we analyzed and compared the inhibitory effects of nine different polyoxotungs...