6 documents found, page 1 of 1
Faster cryptococcus melanization increases virulence in experimental and human ...
Sousa, Herdson Renney de; Oliveira Júnior, Getúlio Pereira de; Frazão, Stefânia de Oliveira; Gorgonha, Kaio César de Melo; Rosa, Camila PereiraCryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neofo...
Cryptococcal virulence in humans : learning from translational studies with cli...
Sousa, Herdson Renney de; Frazão, Stefânia de Oliveira; Oliveira Júnior, Getúlio Pereira de; Albuquerque, Patrícia; Nicola, André MoraesCryptococcosis, an invasive mycosis caused by Cryptococcus spp, kills between 20% and 70% of the patients who develop it. There are no vaccines for prevention, and treatment is based on a limited number of antifungals. Studying fungal virulence and how the host responds to infection could lead to new therapies, improving outcomes for patients. The biggest challenge, however, is that experimental cryptococcosis ...
Laccase affects the rate of Cryptococcus neoformans nonlytic exocytosis from ma...
Frazão, Stefânia de Oliveira; Sousa, Herdson Renney de; Silva, Lenise Gonçalves da; Folha, Jéssica dos Santos; Gorgonha, Kaio César de MeloNonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages and ameboid predators. Despite a great amount of research dedicated to unraveling this process, t...
Avaliação da ocorrência de exocitose não-lítica em isolados clínicos de Cryptoc...
Frazão, Stefânia de OliveiraDissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Pós-graduação em Medicina Tropical, 2018.; Fundação de Apoio a Pesquisa do Distrito Federal (FAD/DF).; A criptococose é uma micose sistêmica adquirida por inalação de propágulos de fungos do Cryptococcus neoformans (Cn) e C. gattii. Cn genotipo VNI é cosmopolita, e causa doença oportunista em indivíduos imunocomprometidos, sendo importante ...
Estudo Sobre Galleria mellonella como um modelo animal alternativo para estudo ...
Frazão, Stefânia de OliveiraBiomedicina; Submitted by Ana Paula Amorim (ana.amorim@ucb.br) on 2016-04-13T22:52:58Z No. of bitstreams: 2 license_rdf: 20618 bytes, checksum: b67ac4fa37d756ac08366dbc4e32ada7 (MD5) StefaniadeOliveiraFrazão.pdf: 603645 bytes, checksum: 93e09496ff4f319186826ab044ba9c67 (MD5); Approved for entry into archive by Kelson Anthony de Menezes(kelson@ucb.br) on 2016-07-05T11:48:10Z (GMT) No. of bitstreams: 2 license_rd...
Estudo Sobre Galleria mellonella como um modelo animal alternativo para estudo ...
Frazão, Stefânia de OliveiraBiomedicina; Submitted by Aguiar Francience (franciene.aguiar@ucb.br) on 2015-07-30T00:25:44Z No. of bitstreams: 2 license_rdf: 20618 bytes, checksum: b67ac4fa37d756ac08366dbc4e32ada7 (MD5) TCC II 2-2014 - Stefania de Oliveira Frazão.pdf: 603645 bytes, checksum: 93e09496ff4f319186826ab044ba9c67 (MD5); Approved for entry into archive by Kelson Anthony de Menezes(kelson@ucb.br) on 2015-09-03T18:08:24Z (GMT) No. o...