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The cerebellum is causally involved in episodic memory under aging

Almeida, Armando; Martins, Ana R.; Amaral, Lénia; Valério, Daniela; Bukhari, Qasim; Schu, Guilherme; Nogueira, Joana; Spínola, Mónica

Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory pe...


Editorial: Optimization strategies for pain management with neuromodulation

Pacheco-Barrios, Kevin; Carvalho, Sandra; Leite, Jorge; Caumo, Wolnei; Fregni, Felipe; Leite, Jorge

Chronic pain is a high-priority global health issue due to its high prevalence, impact on quality of life, and cost (1). In most cases, chronic pain is challenging to manage, and the existing treatment modalities have reported frequent and severe adverse events, including gastritis (2), cardiovascular complications [...]


Digitalized transcranial electrical stimulation: a consensus statement

Brunoni, André R.; Ekhtiari, Hamed; Antal, Andrea; Auvichayapat, Paradee; Baeken, Chris; Benseñor, Isabela M; Bikson, Marom; Boggio, Paulo

Objective: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aim...



Modulation of the cognitive event-related potential P3 by transcranial direct c...

Mendes, Augusto J.; Pacheco-Barrios, Kevin; Lema, Alberto; Gonçalves, Óscar F.; Fregni, Felipe; Carvalho, Sandra; Leite, Jorge

Transcranial direct current stimulation (tDCS) has been widely used to modulate cognition and behavior. However, only a few studies have been probing the brain mechanism underlying the effects of tDCS on cognitive processing, especially throughout electrophysiological markers, such as the P3. This meta-analysis assessed the effects of tDCS in P3 amplitude and latency during an oddball, n-back, and Go/No-Go task...


Working memory training coupled with transcranial direct current stimulation in...

Teixeira-Santos, Ana C.; Moreira, Célia S.; Pereira, Diana R.; Pinal, Diego; Fregni, Felipe; Carvalho, Sandra; Sampaio, Adriana; Leite, Jorge

Background: Transcranial direct current stimulation (tDCS) has been employed to boost working memory training (WMT) effects. Nevertheless, there is limited evidence on the efficacy of this combination in older adults. The present study is aimed to assess the delayed transfer effects of tDCS coupled with WMT in older adults in a 15-day follow-up. We explored if general cognitive ability, age, and educational lev...


The effects of direct current stimulation and random noise stimulation on atten...

Lema, Alberto; Carvalho, Sandra; Fregni, Felipe; Gonçalves, Óscar F.; Leite, Jorge

Attention is a complex cognitive process that selects specific stimuli for further processing. Previous research suggested the existence of three attentional networks: alerting, orienting and executive. However, one important topic is how to enhance the efficiency of attentional networks. In this context, understanding how this system behaves under two different modulatory conditions, namely transcranial direct...


Working memory training coupled with transcranial direct current stimulation in...

Teixeira-Santos, Ana C.; Moreira, Célia S.; Pereira, Diana R.; Pinal, Diego; Fregni, Felipe; Leite, Jorge; Carvalho, Sandra; Sampaio, Adriana

Background: Transcranial direct current stimulation (tDCS) has been employed to boost working memory training (WMT) effects. Nevertheless, there is limited evidence on the efficacy of this combination in older adults. The present study is aimed to assess the delayed transfer effects of tDCS coupled with WMT in older adults in a 15-day follow-up. We explored if general cognitive ability, age, and educational lev...


Editorial: optimization strategies for pain management with neuromodulation

Pacheco-Barrios, Kevin; Carvalho, Sandra; Leite, Jorge; Caumo, Wolnei; Fregni, Felipe

Chronic pain is a high-priority global health issue due to its high prevalence, impact on quality of life, and cost (1). In most cases, chronic pain is challenging to manage, and the existing treatment modalities have reported frequent and severe adverse events, including gastritis (2), cardiovascular complications (2), or even addiction (1) in the case of opioids. Although, during the past two decades, neurosc...


Digitalized transcranial electrical stimulation: a consensus statement

Brunoni, Andre R; Ekhtiari, Hamed; Antal, Andrea; Auvichayapat, Paradee; Baeken, Chris; Benseñor, Isabela M; Bikson, Marom; Boggio, Paulo

Objective: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aim...


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