12 documents found, page 1 of 2
Uso de medicamentos na gravidez: padrões e fatores associados
Medina, Flávia; Rodrigues, Leandra; Coelho, Joana; Nascimento, LuísA gravidez causa alterações fisiológicas que podem aumentar a vulnerabilidade ao aparecimento de doenças e modificar a farmacocinética dos medicamentos Além disso, alguns medicamentos atravessam a placenta e afetam o desenvolvimento fetal, especialmente durante o período da organogénese Esses fatores evidenciam a necessidade de uma monitorização mais cuidadosa e fundamentam iniciativas regulatórias recentes, co...
Medication use during pregnancy: patterns and associated factors
Medina, Flávia; Rodrigues, Leandra; Coelho, Joana; Nascimento, LuísPregnancy causes physiological changes that can increase vulnerability to illness and alter drug pharmacokinetics, while some medications cross the placenta and affect foetal development, especially during organogenesis. These risks highlight the importance of careful monitoring and support regulatory updates such as the FDA’s 2015 revision of pregnancy risk categories. Objectives: To identify factors associate...
An improved reference genome and first organelle genomes of Quercus suber
Usié, Ana; Serra, Octávio; Barros, Pedro M.; Barbosa, Pedro; Leão, Célia; Capote, Tiago; Almeida, Tânia; Rodrigues, Leandra; Carrasquinho, IsabelCork oak (Quercus suber L.) is an ecologically and economically important evergreen tree species native to the Mediterranean region and widespread in southwest Europe and northwest Africa. An improved genome assembly of cork oak using a combination of Illumina and PacBio sequencing is presented in this study. The assembled genome contains 2351 scaffolds longer than 1000 bp, accounting for 765.7 Mbp of genome si...
The draft genome sequence of cork oak
Ramos, António Marcos; Usié, Ana; Barbosa, Pedro; Barros, Pedro M.; Capote, Tiago; Chaves, Inês; Simões, Fernanda; Abreu, Isabl; Carrasquinho, IsabelCork oak (Quercus suber) is native to southwest Europe and northwest Africa where it plays a crucial environmental and economical role. To tackle the cork oak production and industrial challenges, advanced research is imperative but dependent on the availability of a sequenced genome. To address this, we produced the first draft version of the cork oak genome. We followed a de novo assembly strategy based on hi...
The draft genome sequence of cork oak
Ramos, António Marcos; Usié, Ana; Barbosa, Pedro; Barros, Pedro M.; Capote, Tiago; Chaves, Inês; Simões, Fernanda; Abreu, Isabl; Carrasquinho, IsabelCork oak (Quercus suber) is native to southwest Europe and northwest Africa where it plays a crucial environmental and economical role. To tackle the cork oak production and industrial challenges, advanced research is imperative but dependent on the availability of a sequenced genome. To address this, we produced the first draft version of the cork oak genome. We followed a de novo assembly strategy based on hi...
Low genetic diversity and significant structuring in the endangered Mentha cerv...
Rodrigues, Leandra; Berg, Cássio Van den; Póvoa, Orlanda; Monteiro, AnaEighteen populations of the endangered aromatic and medicinal plant Mentha cervina (Lamiaceae) were sampled across its natural range, in the western half of the Iberian Peninsula, and inter-simple sequence repeats (ISSRs) markers were used to assess genetic diversity and population structure. M. cervina populations exhibited a relatively low genetic diversity (percentage of polymorphic loci PPB ¼ 14.2–58.3%, Ne...
Genetic diversity in Mentha cervina based on morphological traits, essential oi...
Rodrigues, Leandra; Póvoa, Orlanda; Berg, Cássio Van den; Figueiredo, Ana Cristina; Moldão, Margarida; Monteiro, AnaMorphological, phytochemical and genetic differences were studied to evaluate the level and distribution of diversity in twelve populations of the Portuguese endangered medicinal plant Mentha cervina L. Morphological variation was correlated with ecological conditions at the site of origin. Pulegone was the major essential oils compound in all of the populations collected at full flowering (68–83%), in differen...
Trichomes micromorphology and essential oil variation at different developmenta...
Rodrigues, Leandra; Póvoa, Orlanda; Teixeira, Generosa; Figueiredo, Ana Cristina; Moldão, Margarida; Monteiro, AnaThe indumentum of Mentha pulegium L., studied by light and scanning electron microscopy, was characterized by non-glandular and glandular trichomes, which corresponded to the common arrangement described for the Lamiaceae family. Histochemistry revealed the presence of pectins, total lipids, acidic lipids and essential oils in the glandular trichomes secretions. The essential oil yield ranged from 0.3% (w/d.w.)...
Chemical composition and antibacterial activity of essential oils from the medi...
Rodrigues, Leandra; Duarte, Aida; Figueiredo, Ana Cristina; Brito, Luísa; Teixeira, Generosa; Moldão, Margarida; Monteiro, AnaMentha cervina is a medicinal plant traditionally used in Portugal in folk medicine, in different gastric disorders and inflammations of the respiratory tract. In order to validate those traditional uses, M. cervina essential oils (EOs) were characterized by GC and GC–MS and their antimicrobial activity was tested against 23 bacterial strains (including multiresistant strains). The EOs were dominated by the mon...
Morphology of secretory structures and essential oil composition in Mentha cerv...
Rodrigues, Leandra; Monteiro, Patricia; Póvoa, Orlanda; Teixeira, Generosa; Moldão, Margarida; Figueiredo, Ana Cristina; Monteiro, AnaABSTRACT: Mentha cervina L. is an aromatic plant that is traditionally used in the Alentejo region of Portugal to flavour food dishes and for the medicinal properties of the essential oil produced in its glandular trichomes. The morphology and distribution of the secretory structures of 20 populations was studied by light and scanning electron microscopy and revealed a great similarity in the type and distribut...