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Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Me...
Martins, Conceição S.; Costa, Deiziane V. S.; Lima, Bruno B.; Leitäo, Renata Ferreira de Carvalho; Freire, Gildênio E.; Silva, Guilherme F. M.Clostridioides difficile toxin A (TcdA) has been shown to inhibit cellular Wnt signaling, the major driving force behind the proliferation of epithelial cells in colonic crypts, likely through the inhibition of β-catenin nuclear translocation. Herein, we aimed to advance the understanding of this mechanism by replicating the findings in vivo and by investigating the specific role of Rac1, a member of the Rho GT...
Date: 2021
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Origin: Oasisbr