4 documents found, page 1 of 1
Analysis of the immunoexpression of opioid receptors and their correlation with...
Sousa, Alceu Machado de; Dantas, Thinali Sousa; Silva, Paulo Goberlânio de Barros; Martins, Conceição da Silva; Freire, Gildenio EstevamObjective: Breast cancer is a disease of great concern. The prognosis of this tumor is related to its staging. Opioids are widely used to minimize pain in oncology clinics; however, the relationship between the administration of opioids and their effects on tumor cells has yet to be elucidated. Therefore, this study aimed to evaluate the immunoexpression of mu- (μ) and kappa- (κ) opioid receptors and their corr...
Efeito do tratamento hidrotérmico com esponja de colágeno impregnadas com nanop...
Freire, Gildenio EstevamThe biocomposites of collagen and hydroxyapatite have been widely used in bone defects treatment, allowing the drug delivery and growth factors, as well as serving as scaffold. They also present osteogenic activity by mechanisms not yet clarified. We evaluated the effect of collagen sponges impregnated with different concentrations of nanohydroxyapatite developed by our research group on murine osteoblasts in c...
Role of the route of leukotrienes in an experimental model of oral mucositis in...
Silva, Viviane Carvalho da; Leitão, Renata Ferreira de Carvalho; Brito, Gerly Anne de Castro; Martins, Conceição da Silva; Freire, Gildenio EstevamPurpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administ...
Evaluation of the chronobiological profile and its relation with the nutritiona...
Santos, Ana Angélica Queiroz Assunção; Souza, Ana Isabel Lima de; Viana, Felipe Araújo Viana; Freire, Gildenio Estevam; Veras, Mariana De Oliveira VianaC hronobiology is responsible for studying the temporal properties of living matter, including all levels of organization, as well as the study of circadian rhythms, which are biological rhythms that oscillate around 24 hours. The objective of the present study was to reveal the chronobiological profile of night workers in an industry, as well as to detect the de gree of influence of shift work conditions on sl...