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Human serum pre-treatment: removal of abundant proteins aiming the concentratio...

Rosa, M; Silva, F; Coutinho, J; Freire, M

Due to the long asymptomatic phase and lack of effective early-stage diagnosis, lung cancer is one of the deadliest types of cancer worldwide. To expedite disease diagnosis, the quantification of target biomarkers in human serum is a propitious approach. However, the low concentrations of biomarkers in human serum and their tendency to be masked by abundant proteins [immunoglobulin G (IgG) and human serum album...


Enzalutamida vs quimioterapia como primeira opção no carcinoma da próstata resi...

Carvalho, J; Nunes, P; Dinis, P; Parada, B; Freire, M; Azinhais, P; Tavares da Silva, E; Brandão, A; Dias, V; Figueiredo, A


Co-morbidities and sleep apnoea severity. A study in a cohort of Portuguese pat...

Silva, L; Cunha, D; Lopes, J; Ramalheira, J; Freire, M; Novío, S; Núñez, MJ; Mendonça, D; Martins-Da-Silva, A

Introduction. Obstructive sleep apnoea syndrome (OSAS) is frequently associated to other morbid conditions that act as risk factors influencing OSAS morbidity and mortality. Aim. To analyse the presence of co-morbidities in OSAS patients, recruited from a sleep outpatient clinic in Northern Portugal, stratified as a function of OSAS severity. Patients and methods. A cohort of 319 sleep-disordered patients was a...


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