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(−)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isola...
Siqueira, Rodrigo José Bezerra de; Ribeiro-Filho, Helder Veras; Freire, R. S.; Freire, W. B. S.; Vasconcelos-Silva, A. A.; Soares, M. A.; Lahlou, SaadPrevious findings enable us to hypothesize that (−)-α-bisabolol acts as inhibitor of voltage-dependent Ca2+ channels in smooth muscle. The current studywas aimed at consolidating such hypothesis through the recording of isometric tension, measurement of intracellular Ca2+ as well as discovery of channel target using in silico analysis. In rat aortic rings, (−)-α-bisabolol (1–1000 μM) relaxed KCl- and phenylephr...
Date: 2014
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Origin: Oasisbr