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Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior...

Moura, Sara Reis; Freitas, Jaime; Ribeiro-Machado, Cláudia; Lopes, Jorge; Neves, Nuno; Canhão, Helena; Rodrigues, Ana Maria; Barbosa, Mário Adolfo

BACKGROUND: The vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poorly studied. The lncRNA H19 mediates osteogenic differentiation of Mesenchymal Stem/Stromal Cells (MSCs) through the control of intracellular pathways. However, the effect of H19 on the extrace...

Date: 2023   |   Origin: Repositório Institucional da UNL
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