4 documents found, page 1 of 1
Prediction of overall survival for patients with metastatic castration-resistan...
Guinney, Justin; Wang, Tao; Laajala, Teemu D.; Winner, Kimberly Kanigel; Bare, J. Christopher; Neto, Elias Chaibub; Khan, Suleiman A.; Peddinti, GopalBackground: Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Ass...
A DREAM challenge to build prediction models for short-term discontinuation of ...
Prostate Cancer DREAM Challenge Community; Correia, Sara; Freitas, Ana Alão; Rocha, Miguel; Vieira, VítorPurpose Docetaxel has a demonstrated survival benefit for patients with metastatic castration-resistant prostate cancer (mCRPC); however, 10% to 20% of patients discontinue docetaxel prematurely because of toxicity-induced adverse events, and the management of risk factors for toxicity remains a challenge. Patients and Methods The comparator arms of four phase III clinical trials in first-line mCRPC were collec...
Extracting kinetic information from literature with KineticRE
Freitas, Ana Alão; Costa, Hugo; Rocha, Miguel; Rocha, I.To better understand the dynamic behavior of metabolic networks in a wide variety of conditions, the field of Systems Biology has increased its interest in the use of kinetic models. The different databases, available these days, do not contain enough data regarding this topic. Given that a significant part of the relevant information for the development of such models is still wide spread in the literature, it...
Extraction of kinetic information from literature
Freitas, Ana AlãoDissertação de mestrado em Informática; Several areas of science and industry are increasingly interested in the use of metabolic models, because they allow in silico simulation of the behavior of organisms under different experimental conditions, optimization and maximization of production of products of interest, the testing of new drugs and the effect of mutations or gene deletions, among others. In most cas...