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Persistent Polyclonal B-Cell Lymphocytosis (PPBL): An Entity That Is Not What i...

Figueiredo, António; Freitas, Ana Carolina; Paulino, Diogo; Severino, Carlos; Calú, Máriam; Barreira, Rui

Persistent polyclonal B-cell lymphocytosis is a rare disease with chronic lymphocytosis of polyclonal origin, which is more frequent in mostly asymptomatic middle-aged female smokers. The hallmark of this entity is the presence of bilobed/binucleated B lymphocytes, which are polyclonal as demonstrated by immunophenotyping; an elevated IgM level is common. This disease shows, in most cases, an indolent course ov...

Date: 2024   |   Origin: Acta Médica Portuguesa
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