3 documents found, page 1 of 1
Mucin-type O-glycosylation in gastric carcinogenesis
Duarte, HO; Freitas, DP; Gomes, C; Gomes, J; Magalhães, A; Reis, CAMucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their glycan products constitute well-established molecular hallmarks of disease state. This review addresses the major role played by mucins and associated O-glycan s...
Helicobacter pylori chronic infection and mucosal inflammation switches the hum...
Magalhães, A; Marcos-Pinto, R; Nairn, A; dela Rosa, M; Ferreira, RM; Junqueira-Neto, S; Freitas, DP; Gomes, J; Oliveira, P; Santos, M; Marcos, NHelicobacter pylori exploits host glycoconjugates to colonize the gastric niche. Infection can persist for decades promoting chronic inflammation, and in a subset of individuals lesions can silently progress to cancer. This study shows that H. pylori chronic infection and gastric tissue inflammation result in a remodeling of the gastric glycophenotype with increased expression of sialyl-Lewis a/x antigens due t...
A comparison of Helicobacter pylori and non-Helicobacter pylori Helicobacter sp...
Amorim, I; Freitas, DP; Magalhães, A; Faria, F; Lopes, C; Faustino, A; Smet, A; Haesebrouck, F; Reis, CA; Gärtner, FBackground: The gastric mucosa of dogs is often colonized by non-Helicobacter pylori helicobacters (NHPH), while H. pylori is the predominant gastric Helicobacter species in humans. The colonization of the human gastric mucosa by H. pylori is highly dependent on the recognition of host glycan receptors. Our goal was to define the canine gastric mucosa glycophenotype and to evaluate the capacity of different gas...