4 documents found, page 1 of 1
In vitro evaluation of the curcumin against fluconazole-resistant strains of Ca...
Freitas, Daniel Domingues; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Sampaio, Letícia SerpaThe isolates of Candida spp. and Cryptococcus neoformans were inhibited by curcumin, with different degrees of inhibition among species, with MICs ranging from 8-64 μg/mL. After exposure of the C. albicans strains to curcumin, it was observed a decrease in the number of viable cells and damage to cell membranes, the mitochondrial function of C. albicans cells appears to be affected after exposure to curcumin. O...
Effects of piperonal nitro derivatives on candida species : antifungal activity...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Freitas, Daniel DominguesRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...
Berberine antifungal activity in fluconazole-resistant pathogenic yeasts : acti...
Silva, Anderson Ramos da; Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Silva, Rose Anny CostaThe incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with bio- film formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a pro- toberberine-type isoquin...
Avaliação in vitro da curcumina frente às cepas de Candida spp. e Cryptococcus ...
Freitas, Daniel DominguesConsidering that some therapeutic properties of curcumin are well described, so the present study points to an antifungal effect of curcumin against strains of pathogenic yeasts resistant to fluconazole, strains of Candida spp. and Cryptococcus neoformans. All strains studied were inhibited by curcumin with different degrees of inhibition among species with MICs ranging from 8-64 mg / ml. After exposure strains...