13 documents found, page 1 of 2
A functional polymorphism in IL-36β modulates macrophage antifungal effector fu...
Gonçalves, Samuel M.; Leite, L.; de Vasconcelos, P.; Pereira, I.; Dewi, I. M. W.; Mercier, T.; Aerts, R.; Ligeiro, D.; Mendes, F.; Freitas, F.Background: Genetic predisposition plays a major role in the development of invasive pulmonary aspergillosis (IPA). The risk and course of IPA vary significantly among patients, yet continuously new genetic mechanisms that influence individual antifungal immune responses are being discovered. While genetic variability in interleukin (IL)-1 family cytokines is recognized as an important cause of disease suscepti...
Effect of ageing treatment on the antibacterial behaviour of cast stainless ste...
Ferraz, MP; Moreira, A.B.; Mota, C.D.; Freitas, F.; Laura Ribeiro; Vieira, MF
Development of a cryoprotective formula based on the fucose-containing polysacc...
Guerreiro, B.M.; Silva, J.C.; Torres, C.A.V.; Delgado Alves, Vitor; Lima, J.C.; Reis, M.A.M.; Freitas, F.This study reports the performance of the polysaccharide FucoPol as an enhancer of cryoprotective formulations. FucoPol at a concentration of 0.25% (w/v) was added to several normothermic Dulbecco-derived solutions and hypothermic Euro- Collins, Custodiol-HTK, and Unisol-CV media, substituting some constituents in the latter class to develop FucoPol-based formulations that were tested for their ability to cryop...
Development of a suitable project management approach for projects with paralle...
Freitas, F.; Silva, Francisco J. G; Campilho, R.D.S.G.; Pimentel, C.; Godina, R.In a big company, project management (PM) is always present. Traditional predictive PM approach is concerned with planning everything in advance and then controlling and adjusting if necessary, throughout the project timeline. This may work well when the requirements are well established, but for maintenance projects brings inherent uncertainty. When the subject is aircraft maintenance, it is almost impossible ...
Simulação de um sensor ótico baseado em microcavidade ressonante para medição d...
Freitas, F.; Facão, M.; Ferreira, M. S.Neste trabalho, foi desenvolvido um algoritmo para simular a propagação do campo eletromagnético num tubo capilar quando acoplado com uma microfibra ótica, com recurso à teoria de dispersão de Mie, determinando os seus modos ressonantes. A utilização de um tubo capilar permite não só o acoplamento de luz, como também a circulação de fluidos no seu interior, apresentando vantagens como elemento sensor. Devido às...
Psychosocial drivers for change: understanding and promoting stakeholder engage...
Luís, S.; Lima, M. L.; Roseta-Palma, C.; Rodrigues, N.; Sousa, L. P.; Freitas, F.; Alves, F. L.; Lillebø, A. I.; Parrod, C.; Jolivet, V.; Paramana, T.Stakeholder engagement in the processes of planning local adaptation to climate change faces many challenges. The goal of this work was to explore whether or not the intention of engaging could be understood (Study 1) and promoted (Study 2), by using an extension of the theory of planned behaviour. In Study 1, stakeholders from three European Mediterranean case studies were surveyed: Baixo Vouga Lagunar (Portug...
A phage-based assay for detection of pathogens
Carvalho, Carla M.; Costa, S.; Melo, Luís Daniel Rodrigues; Santos, Sílvio Roberto Branco; Freitas, F.; Azeredo, JoanaThe incidence of infectious diseases is a major concern worldwide. Their prevention or reduction is dependent on the ability to rapidly identify contributing pathogens. Some phage proteins present potential as probing elements for the detection of pathogens. Examples include the cell wall binding domains (CBDs) of phage endolysins that recognize and bind to the bacterial cell wall and the proteins located at th...
Posttransplant allosensitization in low immunological risk kidney and kidney-pa...
Malheiro, J.; Tafulo, S.; Dias, L.; Martins, La Salete; Fonseca, Isabel; Almeida, M.; Pedroso, S.; Freitas, F.; Beirão, I.; Castro-Henriques, A.INTRODUCTION: Posttransplantation allosensitization prevalence and effect on kidney grafts outcomes remain unsettled. METHODS: Between 2007 and 2012, 408 patients received a primary kidney graft (with 68 patients also receiving a pancreas graft) after a negative cytotoxic crossmatch. All patients had a pretransplant negative anti-HLA screening and 0% panel reactive antibodies. We analyzed retrospectively the re...
Digital Preservation Based on Federations of Data Grids
Antunes, G. J.; Barateiro, J.; Borbinha, J. L.; Silvestre, D.; Freitas, F.Digital preservation, as a research and technical problem, is related with the purpose of maintaining digital objects accessible over a long period of time, regardless the challenges concerning technological or organizational changes or failures. In this poster we propose solutions that can evaluate and support the design of strategies in the context of preser- vation systems based on federations of data grids....
Designing Digital Preservation Solutions:A Risk Management-Based Approach
Barateiro, J.; Antunes, G. J.; Freitas, F.; Borbinha, J. L.Digital preservation aims to keep digital objects accessible over long periods of time, ensuring the authenticity and integrity of these digital objects. In such complex environments, Risk Management is a key factor in assuring the normal behaviour of systems over time. Currently, the digital preservation arena commonly uses Risk Management concepts to assess repositories. In this paper, we intend to go further...