36 documents found, page 1 of 4
Circulating microRNAs as potential biomarkers for genetic generalized epilepsie...
Martins‐Ferreira, R.; Chaves, J.; Carvalho, C.; Bettencourt, A.; Chorão, R.; Freitas, J.; Samões, R.; Boleixa, D.; Lopes, J.; Ramalheira, J.Background and purpose: Genetic generalized epilepsies (GGEs) encompass a group of syndromes of mainly genetic causes, characterized by the involvement of both hemispheres. MicroRNAs (miRNAs) are small non-coding RNAs with a critical role in the regulation of neuronal biological processes through gene expression modulation. Dysregulated miRNA expression has been shown in epilepsy. Due to their stability in biol...
Physiological arousal quantifying perception of safe and unsafe virtual environ...
Leite, S.; Dias, J.; Eloy, S.; Freitas, J.; Marques, S.; Silva Pedro, T.; Ourique, L.Physiological arousal has been increasingly applied to monitor exploration (or navigation) of a virtual environment (VE), especially when the VE is designed to evoke an anxiety-related response. The present work aims to evaluate human physiological reactions to safe and unsafe VEs. We compared the effect of the presence of handrails in the VE in two different samples, young and older adults, through self-report...
Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dysho...
Figueiredo, C.; Falcão, I.; Vilaverde, J.; Freitas, J.; Oliveira, M.; Godinho, C.; Dores, J.; Rodrigues, M.; Carvalho, C.; Borges, T.Fetal goiter is a rare disorder not expected to be found during a healthy woman's pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks' gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without p...
Preliminar study on BDNF regulation by DNA methylation in Mesial Temporal Lobe ...
Ferreira, R.; Leal, B.; Chaves, J.M.M.; Carvalho, C.; Bettencourt, A.; Freitas, J.; Ramalheira, J.E.D.P.; Lopes, J.M.C.F.; Martins da Silva, A.Background and aims: Brain-derived neurotrophic factor (BDNF) is a neurothrophin associated with a wide range of neurophysiological processes, such as neurogenesis, gliogenesis, synaptogenesis and neuroprotection. BDNF has been described as overexpressed in hippocampus of both animal models and Mesial Temporal Lobe Epilepsy (MTLE) patients. Gene expression may be modulated by DNA methylation of the respective p...
MiR-134 serum expression in Mesial Temporal Lobe Epilepsy patients
Leal, B.; Rodrigues, D.; Carvalho, C.; Ferreira, R.; Chaves, J.M.M.; Bettencourt, A.; Freitas, J.; Lopes, J. M.C.F.; Ramalheira, J.E.D.P.Background and aims: Several experimental and clinical studies have suggested that microRNAs (miRNAs) could be potential epilepsy biomarkers. Nowadays, research has been focused in miR-134, a brain-specific miRNA that plays important roles in dendritic spine development and neuronal structure regulation. An upregulation of miR-134 has been reported both in brain tissue of experimental models (Jimenez-Mateos 201...
Amplificação e clonagem de pulsos curtos em amplificadores ópticos paramétricos...
Nascimento, A; Freitas, J.Pulsos curtos são amplamente utilizados nas telecomunicações ópticas por suas características essenciais para sistema de comunicações ópticos em taxas de transmissão de Gbits/s. Assim, estudamos a amplificação de pulsos de 5 ps em um amplificador óptico paramétrico via simulação computacional.
Methodology for single nucleotide polymorphism selection in promoter regions fo...
Marques, Herlander; Freitas, J.; Medeiros, Rui; Longatto Filho, AdhemarGenetic variability in humans can explain many differences in disease risk factors. Polymorphism-related studies focus mainly on the single nucleotide polymorphisms (SNPs) of coding regions of the genes. SNPs on DNA binding motifs of the promoter region have been less explored. On a recent study of SNPs in patients with non-Hodgkin lymphomas we faced the problem of SNP selection from promoter regions and develo...
High-fat diet-induced obesity Rat model: a comparison between Wistar and Spragu...
Marques, C.; Meireles, M.; Norberto, S.; Leite, J.; Freitas, J.; Pestana, D.; Faria, Ana; Calhau, C.In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For the study of these pathologies, a number of animal models have been developed. However, a direct comparison between Wistar and Sprague-Dawley (SD) Rat as models of high-fat (HF) diet-induced obesity has not been adequately evaluated so far. Wistar and SD rats were assigned for 2 experimental groups for 17 ...
Expression of miR146-a, an inflammation-associated microRNA, in Mesial Temporal...
Leal, B.; Carvalho, C.; Chaves, J.; Bettencourt, A.; Freitas, J.; Lopes, J.; Ramalheira, J.; Martins da Silva, A.; Costa, P. P.; Martins da Silva, B.Background: Neuroinflammation appears as an important epileptogenic mechanism. MicroRNAs (miRNA) are small non-coding RNA molecules that function as post-transcriptional regulators of gene expression. MicroRNas control different biological process including immune system homeostasis and function. Several evidences, both in patients and animal studies, have demonstrated an abnormal brain expression of miR-146a i...
High-fat diet-induced obesity rat model: a comparison between wistar and spragu...
Marques, C.; Meireles, M.; Norberto, S.; Leite, J.; Freitas, J.; Pestana, D.; Faria, Ana; Calhau, C.[abstract]