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Long-term blood-free rearing of Anopheles mosquitoes with no effect on fitness,...
Marques, Joana; Seabra, Sofia G.; Almeida, Inês; Gomes, Joana; Alves, Ana Catarina; Silveira, HenriqueFunding Information: We would like to thank Lidia M. D. Gon\u00E7alves (Principal Investigator at the Faculdade de Farm\u00E1cia from Universidade de Lisboa) for technical support. This work was financed by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia Aga-Khan De-velopment Network (FCT-AGAKHAN/541725581/2019) and has received resources funded by the European Union\u2019s Horizon 2020 research and innovat...
Profilaxia pré-exposição para o vírus da imunodeficiência humana no currículo m...
Duarte, Francisco; Rua, Nuno; Gomes, David; Ricoca Peixoto, Vasco; Azevedo, Daniela; Graça, Duarte; Teixeira, Inês; Fernandes, Inês; Frutuoso, JoãoPublisher Copyright: Copyright © Ordem dos Médicos 2022.; Introduction: Pre-exposure prophylaxis (PrEP) has gained relevance as a method of prevention for HIV in certain people and settings. Following the publication of the guideline on PrEP prescribing in Portugal, we aimed to assess the knowledge of Portuguese Medical Students about PrEP. Material and Methods: An online survey was sent to Medical students of ...
Drug-Derived Surface-Active Ionic Liquids
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise; Nogueira, Fátima; Prudêncio, MiguelFunding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH; In...
Profiling Persistent Asthma Phenotypes in Adolescents
Amaral, Rita; Jácome, Cristina; Almeida, Rute; Pereira, Ana Margarida; Alves-Correia, Magna; Mendes, Sandra; Rodrigues, José Carlos CidraisFunding: This research was funded by ERDF (European Regional Development Fund) through the operations: POCI-01-0145-36 FEDER-029130 (“mINSPIRE—mHealth to measure and improve adherence to medication in chronic respiratory diseases—generalisation and evaluation of gamification, peer support and advanced image processing technologies”) cofunded by the COMPETE2020 (Programa Operacional Competitividade e Internacion...
Building on surface-active ionic liquids for the rescuing of the antimalarial d...
Silva, Ana Teresa; Lobo, Lis; Oliveira, Isabel S.; Gomes, Joana; Teixeira, Cátia; Nogueira, Fátima; Marques, Eduardo F.; Ferraz, Ricardo; Gomes, PaulaIonic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50...
Heparin administered to Anopheles in membrane feeding assays blocks Plasmodium ...
Lantero, Elena; Fernandes, Jessica; Aláez-Versón, Carlos Raúl; Gomes, Joana; Silveira, Henrique; Nogueira, Fatima; Fernàndez-Busquets, XavierInnovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes. The transition between ookinete and oocyst pathogen stages in the mosquito has been stu...
Meglumine antimoniate and miltefosine combined with allopurinol sustain pro-inf...
Marcos Ferreira, Santos,; Graça Maria, Alexandre-Pires,; Pereira, Maria A; Cátia S., Marques,; Gomes, Joana; Jorge Jesus, Correia,Canine leishmaniosis (CanL) caused by Leishmania infantum is a zoonotic disease of global concern. Antileishmanial drug therapies commonly used to treat sick dogs improve their clinical condition, although when discontinued relapses can occur. Thus, the current study aims to evaluate the effect of CanL treatments in peripheral blood, lymph node, and bone marrow cytokine profile associated with clinical recovery...
A detection and quantification label-free tool to speed up downstream processin...
Carvalho, Sofia B.; Moreira, Ana Sofia; Gomes, Joana; Carrondo, Manuel J.T.; Thornton, David J.; Alves, Paula M.; Costa, Julia; Peixoto, CristinaMucins are high-molecular weight glycoproteins (0.25–20 MDa) containing one or more domains that are heavily O-glycosylated. Their implications as targets for cancer treatment have increased the interest in these glycoproteins, mainly in the fields of vaccines and antibodies. However, mucins present high heterogeneity, posing challenges that affect purification processes and quality control analysis. In that se...