39 documents found, page 1 of 4
Revealing the immunomodulatory potential of pyrazoles and exploring structure-a...
Silva, Jorge Miguel Almeida; Rocha, S.; Silva, V. L. M.; Silva, A. M. S.; Moreira, Fernando; Fernandes, E.; Freitas, M.Inflammation is a complex and tightly regulated process by a cascade of events that involves the production of prostaglandins (PG) by the inducible isoform cyclooxygenase 2 (COX-2) and the production of reactive pro-oxidant species. Conversely, COX-1, which is consistently present in a variety of tissues, has traditionally been categorized as the primary isoform responsible for maintaining the balance of prosta...
Sustainable lipase production by Diutina rugosa NRRL Y-95 through a combined us...
Freitas, M.; Cavalcante, Lucas S.; Gudiña, Eduardo José; Silvério, Sara Isabel Cruz; Rodrigues, Sueli; Rodrigues, L. R.; Gonçalves, Luciana R. B.The potential use of alternative culture media towards the development of a sustainable bioprocess to produce lipases by Diutina rugosa is clearly demonstrated. First, a synthetic medium containing glucose, peptone, yeast extract, oleic acid, and ammonium sulfate was proposed, with lipase activity of 143 U/L. Then, alternative culture media formulated with agro-industrial residues, such as molasses, corn steep ...
Structure-antifouling activity relationship and molecular targets of bio-inspir...
Almeida, J.R.; Palmeira, A.; Campos, A.; Cunha, I.; Freitas, M.; Felpeto, A.B.; Turkina, M.V.; Vasconcelos, V.; Pinto, M.; Correia-Da-silva, M.The development of alternative ecological and effective antifouling technologies is still challenging. Synthesis of nature-inspired compounds has been exploited, given the potential to assure commercial supplies of potential ecofriendly antifouling agents. In this direction, the antifouling activity of a series of nineteen synthetic small molecules, with chemical similarities with natural products, were exploit...
Failure analysis of cylinder head studs of a four stroke marine diesel engine
Fonte, M.; Reis, L.; Infante, V.; Freitas, M.After about seven years in service, four cylinder head studs, which tight the block and cylinder heads of a marine main engine, have fractured. Meantime, they were changed for new ones without to determine the root cause of failure. The aim of this research work is to carry out a failure analysis in order to avoid recurrent damages in that engine. The fracture morphology and thread roots of fractured studs were...
Failure mode analysis of a damaged diesel motor crankshaft
Afonso Fonte, M.; Reis, L.; Freitas, M.A case study of a catastrophic failure of a diesel motor crankshaft is presented. The aim of this failure analysis is to investigate the root cause of this important mechanical component. This crankshaft belonged to a particular vehicle (140 cv, at 4000 rpm, 1968 cm3 displacement) that fractured after 180,000 km and 8 years in service. The motor was disassembled, and the crankpin No. 3 and the main bearing cap ...
An algorithm for fatigue crack growth applied to mixed and biaxial mode loadings
Baptista, Ricardo; Infante, V.; Freitas, M.Fatigue is still one of the main concerns when dealing with mechanical components failure. While it is fundamental to experimentally determine the fatigue material behavior using standard specimens, testing large and complex component geometries can be complicated. In these cases, the Finite Element Method can be a cost-effective solution but developing fatigue crack growth models is still a complicated task. I...
Pockmarks and fluid migration in the Estremadura Spur, Western Iberian Margin.
Magalhães, Vítor; Duarte, Débora; Freitas, M.; Escada, Claudia; Terrinha, Pedro; Ribeiro, Carlos; Pinheiro, Luis; Cepeda, C.; Correia, R.A field with more than 70 pockmarks in the Estremadura Spur outer shelf on the Western Iberia margin is the main focus of research of the PES project. High-resolution seismic reflection profiles and multibeam bathymetry allowed the characterization of the seismic sequence of a Pliocene-Quaternary basin as well as the pockmark field therein. The Pliocene-Quaternary basin developed on top of a folded, most probab...
Damage evaluation under complex fatigue loading conditions
Reis, Luis; Caxias, J.; Soares, Henrique; Rodrigues da Costa, Pedro; Anes, Vitor; Freitas, M.Fatigue damage and life assessment of multiaxial loadings is still an issue yet to resolve. Many methods have been proposed with promising agreements with the experimental results. However, the performance of such methods is, more than often, purely based on fatigue tests with simple loading conditions. In this work the stress scale factor (SSF) criterion and the virtual cycle counting (vcc) method are used to ...
Failure analysis of a crankshaft of a helicopter engine
Afonso Fonte, M.; Freitas, M.; Infante, V.A detailed analysis of a crankshaft failure belonging to a helicopter engine is presented. The main objective of this work was to analyze the characteristics of the failure and determine the root cause of the failure of the crankshaft. In order to determine the causes of the crankshaft failure, a material analysis was performed, followed by a detailed observation of the failure mechanisms through macroscopic, m...
Frequency of hidden and semi hidden constipation in children with enuresis
Maffei, H. V. [UNESP]; Benini, V.; Vidolin, E.; Reis, J.; Quintanilha, J.; Freitas, M.; Salgado, A.; Trigo Rocha, F.Made available in DSpace on 2018-11-26T15:31:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-10-01; Univ Estadual Paulista, Fac Med Botucatu, UNESP, Botucatu, SP, Brazil; Hosp Municipal Infantil Menino Jesus, Sao Paulo, Brazil; Univ Estadual Paulista, Fac Med Botucatu, UNESP, Botucatu, SP, Brazil