60 documents found, page 1 of 6
One-Pot Microfluidics to Engineer Chitosan Nanoparticles Conjugated with Antimi...
Fonseca, D R; Alves, PM; Neto, E; Custodio, B; Guimaraes, S; Moura, D; Annis, F; Martins, M; Gomes, A; Teixeira, C; Gomes, P; Pereira, RF; Freitas, PSurface bioconjugation of antimicrobial peptides (AMP) onto nanoparticles (AMP-NP) is a complex, multistep, and time-consuming task. Herein, a microfluidic system for the one-pot production of AMP-NP was developed. Norbornene-modified chitosan was used for NP production (NorChit-NP), and thiolated-AMP was grafted on their surface via thiol-norbornene "photoclick" chemistry over exposure of two parallel UV LEDs....
The Impact of Cholecystectomy in Patients with Post-Bariatric Surgery Hypoglycemia
Sardão, D; Santos-Sousa, H; Peleteiro, B; Resende, F; Costa-Pinho, A; Preto, J; Lima-da-Costa, E; Freitas, PBackground: Metabolic surgery is the foremost treatment for obesity and its associated medical conditions. Nonetheless, post-bariatric hypoglycemia (PBH) emerges as a prevalent complication. PBH pathophysiology implicates heightened insulin and glucagon-like peptide 1 (GLP-1) levels, with bile acids (BA) contributing to GLP-1 release. A plausible association exists between cholecystectomy and PBH, which is attr...
Long-term neurological complications in COVID-19 survivors: study protocol of a...
Araújo, N; Silva, I; Campos, P; Correia, R; Calejo, M; Freitas, P; Seco, M; Ribeiro, L; Costa, AR; Morais, S; Pereira, S; Firmino-Machado, JBackgroundEvidence suggests an association between SARS-CoV-2 infection and worse performance on cognitive tests, and a higher risk of Parkinson's disease (PD) and dementia up to 6 and 12 months after infection, respectively. Longer follow-ups with comparison groups are needed to clarify the potentially increased risk of neurodegenerative diseases in COVID-19 survivors, namely those infected before mass vaccina...
Incidental versus symptomatic nonfunctioning pituitary adenomas: Are they diffe...
Guerreiro, V; Mendonça, F; Ferreira, HU; Freitas, P; Pereira, J; Bernardes, I; Pinheiro, J; Guimarães, T; Carvalho, DBackground Nonfunctioning pituitary adenomas (NFPAs) constitute one of the most common tumours in the sellar region and are often discovered only when associated with compressive symptoms. With the frequent use of brain imaging, there has been an increase in the prevalence of incidentally discovered NFPAs.Aim We aim to determine the prevalence of incidental diagnosis with NPAs observed over a decade and compare...
Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and ca...
Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Borges-Canha, M; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, EBackground: One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim: We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with ca...
Validation of App and Phone Versions of the Control of Allergic Rhinitis and As...
Jácome, C; Pereira, AM; Almeida, R; Amaral, R; Correia, MA; Mendes, S; Vieira-Marques, P; Ferreira, JA; Lopes, I; Gomes, J; Vidal, C; López Freire, S
Pancreatic Intraductal Papillary Mucinous Neoplasm Associated Colloid Carcinoma
Flor-de-Lima, B; Freitas, P; Couto, N; Castillo-Martin, M; Santiago, IColloid carcinomas are rare pancreatic tumors characterized by the presence of mucin pools with scarce malignant cells. Most of these neoplasms arise from intestinal-type intraductal papillary mucinous neoplasms (IPMNs). We report a case of a 77-year-old male patient who presented with weight loss, asthenia, lumbar pain and diabetes. Imaging studies revealed a mixed-type IPMN with high-risk features and a possi...
The impact of vitamin d in non-alcoholic fatty liver disease: A cross-sectional...
Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, JPurpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. ...
Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery
Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; M Cabral, P; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, JBackground: Obesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain. Aim: To evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery...
Mixed medullary-papillary thyroid carcinoma with mixed lymph node metastases: A...
Guerreiro, V; Costa, C; Oliveira, J; Santos, AP; Farinha, M; Jácome, M; Freitas, P; Carvalho, D; Torres, IMixed medullary-follicular-derived carcinoma is a very rare event. It is extremely important to make the correct diagnosis, due to prognostic and treatment implications. A genetic study of these patients is advisable to exclude the presence of MEN 2.