4 documents found, page 1 of 1
ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric ...
Oriá, Reinaldo B.; Freitas, Raul S.; Roque, Cássia R.; Nascimento, José Carlos R; Silva, Ana Paula; Malva, João O.; Guerrant, Richard L.Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the ...
Revisiting inbred mouse models to study the developing brain: the potential rol...
Oriá, Reinaldo B.; Malva, João O.; Foley, Patricia L.; Freitas, Raul S.; Bolick, David T.; Guerrant, Richard L.The life-long cumulative exposures (exposome) to environmental contaminants (even low-grade lead, mercury, arsenic etc.) and biological hazards (favoring enteric pathogens and altered “unhealthy” intestinal microbiota) alone or in combination are now being increasingly recognized to deleteriously influence the brain's development and potentially the way the brain copes with aging-related conditions, including n...
Docosanoids promote neurogenesis and angiogenesis, blood-brain barrier integrit...
Belayev, Ludmila; Hong, Sung-Ha; Menghani, Hemant; Marcell, Shawn J.; Obenaus, Andre; Freitas, Raul S.; Khoutorova, Larissa; Balaszczuk, VeronicaDocosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days...
Revisiting Inbred Mouse Models to Study the Developing Brain: The Potential Rol...
Oriá, Reinaldo B.; Malva, João O.; Foley, Patricia L; Freitas, Raul S.; Bolick, David T.; Guerrant, Richard L.Brazilian National Council for Scientific and Technological Development [CNPq] especial visiting researcher [N◦03/2014, # 400538/2014-8; Coordination for the Improvement of Higher Education Personnel [CAPES] Procad [071/2013 # 144494]; Bill and Melinda Gates Foundation grant # OPP1137923. Portugal - CENTRO-01-0145-FEDER-000012: HealthyAgeing 2020 and CENTRO-01-0145-FEDER-000008: BrainHealth 2020.