Made available in DSpace on 2018-11-26T15:28:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Co-stimulatory molecules are essential in the orchestration of immune response and polymorphisms in their genes are associated with various diseases. However, in the case of variable allele frequencies among continental populations, t...