5 documents found, page 1 of 1
Antischistosomal activity of the terpene nerolidol
Silva, Marcos P.N.; Oliveira, George L.S.; Carvalho, Rusbene B.F. de; Sousa, Damião P. de; Freitas, Rivelilson M.; Pinto, Pedro L.S.; Moraes, Josué deSchistosomiasis is a neglected tropical disease that affects hundreds of millions of people worldwide. Since the treatment of this disease currently relies on a single drug, praziquantel, new and safe schistosomicidal agents are urgently required. Nerolidol, a sesquiterpene present in the essential oils of several plants, is found in many foods and was approved by the U.S. Food and Drug Administration. In this ...
Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory...
Quintans, Jullyana S.S.; Barreto, Rosana S.S.; Lucca Júnior, Waldecy de; Villarreal, Cristiane F.; Kaneto, Carla M.; Soares, Milena B.P.Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as ‘sisal’, and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the OPEN ACCESSMolecules 2014, 19 8304 antihyperalgesic profile of HA i...
Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropi...
Moraes, Josué de; Oliveira, Rosimeire Nunes de; Costa, Jéssica P.; Gomes Junior, Antonio Luiz; Sousa, Damião Pergentino de; Freitas, Rivelilson M.Background: Schistosomiasis is a major endemic disease that affects hundreds of millions worldwide. Since the treatment and control of this parasitic disease rely on a single drug, praziquantel, it is imperative that new effective drugs are developed. Here, we report that phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, possesses promising antischistosomal pro...
Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammat...
Damasceno, Samara Rodrigues Bonfim; Oliveira, Francisco Rodrigo A.M.; Carvalho, Nathalia S.; Brito, Camila F.C.; Silva, Irismara S.Aims: The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice. Main methods: The anti-inflammatory activity was evaluated using various phlogistic agents that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, pro and anti-inflammatory cytokine levels. Evaluation of antinociceptive activity was...
Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cyt...
Silva, Renan O.; Sousa, Francisca Beatriz M.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Silva, Valdelânia G.Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and oxidative stress. The anti-inflammatory activities of phytol were assessed by measuring paw edema...