2 documents found, page 1 of 1
Activity of scorpion venom-derived antifungal peptides against planktonic cells...
Guilhelmelli, Fernanda; Vilela, Nathália; Smidt, Karina S.; Oliveira, Marco Antônio de; Álvares, Alice da Cunha MoralesThe incidence of fungal infections has been increasing in the last decades, while the number of available antifungal classes remains the same. The natural and acquired resistance of some fungal species to available therapies, associated with the high toxicity of these drugs on the present scenario and makes an imperative of the search for new, more efficient and less toxic therapeutic choices. Antimicrobial pep...
The Trypanosoma cruzi virulence factor Oligopeptidase B (OPBTc) assembles into ...
Motta, Flávia da Silva Nader; Bastos, Izabela Marques Dourado; Faudry, Eric; Ebel, Christine; Lima, Meire Maria de; Neves, David; Ragno, MichelOligopeptidase B, a processing enzyme of the prolyl oligopeptidase family, is considered as an important virulence factor intrypanosomiasis. Trypanosoma cruzi oligopeptidase B (OPBTc) is involved in host cell invasion by generating a Ca2+-agonist necessary for recruitment and fusion of host lysosomes at the site of parasite attachment. The underlying mechanism remains unknown and further structural and function...