37 documents found, page 1 of 4
Age-Related Normative Data and Percentile Ranges for Serum Neurofilament Light ...
Spínola, Anuschka; Tábuas-Pereira, Miguel; Leitão, Maria João; Bernardes, Catarina; Lima, Marisa; Durães, João; Freitas, Sandra; Santana, IsabelIntroduction: Blood-based neurofilament light chain (NfL), a neuronal cytoskeleton protein, has proven to be a dynamic and robust biomarker for neurodegeneration. The influence of age on NfL levels has been extensively documented in cerebrospinal fluid studies, with blood quantification showing similar trends. To aid the clinical interpretation of NfL values, it is crucial to establish normal reference interval...
Association between aluminium levels and cognitive decline in environmentally e...
Gerardo, Bianca; Pinto, Marina Cabral; Nogueira, Joana; Almeida, Agostinho; Pinto, Edgar; Simões, Mário Rodrigues; Freitas, SandraNormal brain functioning depends on metals homeostasis, as imbalances may increase oxidative stress and cause other detrimental intracellular events that lead to cell loss. Furthermore, environmental exposure to toxic metals is hypothesized to induce neuroinflammation and neuropathology, paving the way to neurodegeneration. The aim of this study was to examine whether such Potentially Toxic Elements (PTE) are a...
The Assessment of Cognitive Reserve: A Systematic Review of the Most Used Quant...
Nogueira, Joana; Gerardo, Bianca Salguinho; Santana, Isabel; Simões, Mário R.; Freitas, SandraThe cognitive reserve (CR) is widely accepted as the active ability to cope with brain damage, using preexisting cognitive and compensatory processes. The common CR proxies used are the number of formal years of education, intelligence quotient (IQ) or premorbid functioning, occupation attainment, and participation in leisure activities. More recently, it has employed the level of literacy and engagement in hig...
Cognitive decline complaints scale (CDCS): validation and normative studies for...
Frias, Joana Rita; Nogueira, Joana; Gerardo, Bianca; Afonso, Rosa Marina; Freitas, SandraObjectives: Subjective Cognitive Complaints, which result from the self-perception of Subjective Cognitive Decline, are frequently reported by older adults. The Cognitive Decline Complaints Scale (CDCS) assesses subjective complaints of cognitive decline in several cognitive domains through three levels of severity. This study aims to psychometrically validate this instrument considering the Classical Test Theo...
Decision-making Capacity in Healthcare: Instruments Review and Reflections abou...
Amaral, Ana Saraiva; Afonso, Rosa Marina; Simões, Mário R.; Freitas, SandraThis is a post-peer-review, pre-copyedit version of an article published in Psychiatric Quarterly. The final authenticated version is available online at: https://doi.org/10.1007/s11126-020-09867-7; The prevalence of neurodegenerative diseases has been significantly increasing in the last decades, and it is expected to continue to grow. These health disorders can impair patients’ decision-making capacity in hea...
Sentidos atribuídos por jovens escolares LGBT à afetividade e à vivência da sex...
Freitas, Sandra; Bermúdez, Ximena Pamela Díaz; Mérchan-Hamann, EdgarThis paper studies the narratives of young school students self-identified as part of the social segments of lesbians, gays, bisexuals and trans people (LGBT), who acted as protagonists in projects to promote health and defend human rights in school contexts. The study is based on qualitative methodological approach such as life history and in-depth interviews, aiming to understand the meanings attributed to th...
Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Yea...
Gerardo, Bianca; Pinto, Marina Cabral; Nogueira, Joana; Pinto, Paula; Almeida, Agostinho; Pinto, Edgar; Marinho-Reis, Paula; Diniz, LuísaTrace elements (TE) homeostasis is crucial in normal brain functioning. Although imbalances have the potential to exacerbate events leading neurodegenerative diseases, few studies have directly addressed the eventual relationships between TE levels in the human body and future cognitive status. The present study aimed to assess how different TE body-levels relate to cognitive decline. This exploratory research ...
Associations between trace elements and cognitive decline: an exploratory 5-Yea...
Gerardo, Bianca; Pinto, Marina Cabral; Nogueira, Joana; Pinto, Paula; Almeida, Agostinho; Pinto, Edgar; Marinho-Reis, Paula; Diniz, LuísaTrace elements (TE) homeostasis is crucial in normal brain functioning. Although imbalances have the potential to exacerbate events leading neurodegenerative diseases, few studies have directly addressed the eventual relationships between TE levels in the human body and future cognitive status. The present study aimed to assess how different TE body-levels relate to cognitive decline..
Associations between trace elements and cognitive decline: an exploratory 5-yea...
Gerardo, Bianca; Cabral Pinto, Marina; Nogueira, Joana; Pinto, Paula; Almeida, Agostinho; Pinto, Edgar; Marinho Reis, A. Paula; Diniz, LuísaTrace elements (TE) homeostasis is crucial in normal brain functioning. Although imbalances have the potential to exacerbate events leading neurodegenerative diseases, few studies have directly addressed the eventual relationships between TE levels in the human body and future cognitive status. The present study aimed to assess how different TE body-levels relate to cognitive decline. This exploratory research ...
Application of sensory methodology for comparing cheese made with Cynara cardun...
Conceição, Cristina; Silva, Flavio; Garrido, Ana; Machado, Eliana; Machado, Graça; Freitas, Sandra; Alvarenga, Nuno; Dias, João; Martins, PedroApplication of sensory methodology for comparing cheese made with Cynara cardunculus coagulant and animal rennet Cristina Conceicao1,2, Flávio Silva2, Ana Garrido2, Francisca Machado2, Graça Machado1,2, Bartolomeu Alvarenga3,4,5, João Dias3,6, João Carvalho3, António Martins4,5, Fátima Duarte7,1 1ICAAM, Portugal. 2U. Évora, Portugal. 3ESA, Portugal. 4UTI-INIAV, Portugal. 5LEAF-ISA, Portugal. 6GeoBioTec, Portuga...