16 documents found, page 1 of 2
Preparação e caracterização do complexo de inclusão do óleo essencial de Croton...
Aguiar,Ulisses N.; Lima,Sidney G. de; Rocha,Márcio S.; Freitas,Rivelilson Mendes de; Oliveira,Talita M.; Silva,Raiane M.; Moura,Lara C. B.Croton zehntneri, a plant native to northeastern Brazil, is widely used in folk medicine to treat gastrointestinal problems and has rich essential oil content. The essential oil of C. Zehntneri was analyzed by GC-MS, and its inclusion complex with β-cyclodextrin (β-CD) was characterized by both vibrational spectroscopy and differential scanning calorimetry (DSC). Estragol was the major component identified in t...
Atividade anticolinesterásica e perfil químico de uma fração cromatográfica ati...
Marques,Thiago Henrique Costa; Santos,Pauline Sousa dos; Freitas,Rivelilson Mendes de; Carvalho,Rusbene Bruno Fonseca de; Melo,Cassio Herbert Santos deThis work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic ¹H NMR, IR and UV data. EEF or flavo...
Composição química e atividade anticolinesterásica de uma fração ativa do extra...
Carvalho,Rusbene Bruno Fonseca de; Almeida,Antonia Amanda Cardoso de; Freitas,Rivelilson Mendes de; Lima,Luciano Silva; David,Juceni PereiraThis paper describes the chemical composition and acetylcholinesterase inhibition of an active chromatographic fraction of the EtOAc extract of Citrus limon leaves. The composition of the active fraction presented a mixture of two coumarins, 5,8-dimethoxy-psoralen and 5,7- dimethoxycoumarin, identified by ¹H and ¹³C NMR data analysis, including DEPT, COSY, HMBC and HSQC experiments. It was also demonstrated tha...
Chemical composition and anxiolytic-like effects of the Bauhinia platypetala
Santos,Francisco José Borges dos; Lima,Sidney Gonçalo de; Cerqueira,Gilberto S.; Citó,Antônia Maria das Graças LopesThe pantropical genus Bauhinia, Fabaceae, known popularly as cow's foot, is widely used in folk medicine as antidiabetic. Behavioral effects of the ethanolic extract and ethereal, aqueous and ethyl acetate fractions from B. platypetala Benth. ex Hemsl. leaves were studied in male Swiss mice. The ethanolic extract and fractions were administered intraperitoneally and its effects on spontaneous motor activity (to...
In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects ...
Marques,Thiago Henrique Costa; Melo,Cássio Herbert Santos de; Freitas,Rivelilson Mendes deAcute toxicity, antioxidant activity in vitro and general pharmacological effects of the flower crude ethanolic extract of Bellis perennis L., Asteraceae, a popular medicine used in South America, were investigated in mice. The oral route LD50 value was found 2.31 g/kg. Oral administration at doses 50, 100 and 150 mg/kg of the extract neither caused significant changes in general behavior nor led to toxic sympt...
Identification and analysis of antinutritional factors in possible interactions...
Campos,Adnny Fernanda Lima; Torres,Savina Pereira; Lopes,Everton Moraes; Carvalho,Rumão Batista Nunes de; Freitas,Rivelilson Mendes deABSTRACT Objective: To identify and analyze the presence of antinutritional factors in possible interactions between medications and foods/ nutrients of the diets prescribed for patients of the Hospital Regional Justino Luz, in the city of Picos (PI) in order to suggest their likely mechanisms. Methods: The sample was made up of 120 medical records of hospitalized patients. The charts were analyzed to verify th...
Antioxidant mechanisms of iso-6-cassine in suppressing seizures induced by pilo...
Freitas,Rivelilson Mendes de; Silva,Fábio de Oliveira; Silva,Maria Goretti de Vasconcelos; Feng,DejiangThe aim of this study was to evaluate the in vitro antioxidant effects of 12-[(2R,5R,6R)-5-hydroxy-6-methylpiperidin-2-yl]dodecan-2-one (iso-6-cassine; ISO) and the anticonvulsant effects of ISO on pilocarpine-induced seizures in rats. Wistar rats were treated with 0.9% saline (i.p., control group), pilocarpine (400 mg/kg, i.p., pilocarpine group), and the association of ISO (1.0 mg/kg, i.p.) plus pilocarpine (...
Evaluation of central nervous system effects of Citrus limon essential oil in mice
Campêlo,Lidianne Mayra Lopes; Lima,Sidney Gonçalo de; Feitosa,Chistiane Mendes; Freitas,Rivelilson Mendes deThe central nervous system (CNS) depressant and anticonvulsant activities of Citrus limon (L.) Osbeck, Rutaceae, essential oil (EO) were investigated in animal models. The EO (50, 100 and 150 mg/kg) injected by oral route (p.o.) in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to thirty days after the administration and the dose of 150 mg/kg signifi...
Evaluation of effects of dichloromethane fraction from Platonia insignis on pil...
Costa Júnior,Joaquim S. da; Ferraz,Alexandre de B. F.; Feitosa,Chistiane Mendes; Citó,Antonia Maria das Graças Lopes; Saffi,JeniferThe objective of present study was to evaluate the antioxidant and anticonvulsant activities of dichloromethane fraction (DMF) from Platonia insignis Mart., Clusiaceae. The DMF from P. insignis (2 mg/kg) was tested by intraperitoneal (i.p.) to evaluate effects on lipid peroxidation level, nitrite formation, as well as on locomotor and anticonvulsant activities. Wistar rats were treated with, (saline/Tween 80 0....
Analysis of possible food/nutrient and drug interactions in hospitalized patients
Lopes,Everton Moraes; Carvalho,Rumão Batista Nunes de; Freitas,Rivelilson Mendes deABSTRACT Objective: To evaluate the prescription in relation to the possible interactions between drugs and foods/nutrients in the diets of patients in the Hospital Regional Justino Luz in the municipality of Picos, Piauí, Brazil. Methods: The sample consisted of 60 medical records of patients admitted at the hospital. The records were analyzed according to the presence or absence of interactions between drugs ...