4 documents found, page 1 of 1
Camelized rabbit-derived VH single-domain Intrabodies Against vif strongly neut...
da Silva, FA; Santa-Marta, M; Freitas-Vieira, A; Mascarenhas, P; Barahona, I; Moniz-Pereira, J; Gabuzda, D; Goncalves, JWe recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a
Functional neutralization of HIV-1 Vif protein by intracellular immunization in...
Goncalves, J; Silva, F; Freitas-Vieira, A; Santa-Marta, M; Malho, R; Yang, X; Gabuzda, D; Barbas, CHuman immunodeficiency virus type 1 (HIV-1) encoded Vif protein is important for viral replication and infectivity. Therefore, Vif is considered to be an important alternative therapeutic target for inhibition of viral infectivity at the level of viral as
Functional neutralization of HIV-1 Vif protein by intracellular immunization in...
Goncalves, J; Silva, F; Freitas-Vieira, A; Santa-Marta, M; Malho, R; Yang, XY; Gabuzda, D; Barbas, CHuman immunodeficiency virus type 1 (HIV-1)-encoded Vif protein is important for viral replication and infectivity. Vif is a cytoplasmic protein that acts during virus assembly by an unknown mechanism, enhancing viral infectivity. The action of Vif in producer cells is essential for the completion of proviral DNA synthesis following virus entry. Therefore, Vif is considered to be an important alternative therap...
Survey of Klebsiella pneumoniae producing extended-spectrum beta-lactamases at ...
Barroso, H; Freitas-Vieira, A; Lito, LM; Cristino, JM; Salgado, MJ; Neto, HF; Sousa, JC; Soveral, G; Moura, T; Duarte, AOne hundred and thirty-eight isolates of Klebsiella pneumoniae showing resistance to ceftazidime were isolated from different wards of the Hospital de Santa Maria, Lisbon, The genomic DNA of the isolates was analysed by pulsed-field gel electrophoresis (PFGE) and two patterns were predominant. In all isolates the presence of a single large plasmid of about 50 kb suggested that propagation of the outbreak promin...